2. Gene
  3. Il21 - interleukin 21 Gene

Il21 - interleukin 21 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IL-21

Gene ID: 60505 | Gene type: protein coding

About Il21

Summary

Enables cytokine receptor binding activity. Involved in cellular response to virus; lymphocyte activation involved in immune response; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of cytokine production; positive regulation of natural killer cell differentiation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in extracellular space. Is expressed in ductus deferens; epididymis; and testis. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21). [provided by Alliance of Genome Resources, Apr 2022]

Il21 Products(2)

mRNA Protein Name
NM_001291041.1 NP_001277970.1 interleukin-21 isoform 1 precursor
NM_021782.3 NP_068554.1 interleukin-21 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cytokine receptor binding IDA
IDA: Inferred from direct assay
11081504 MGI
Biological Process GO Annotation Evidence Reference Source
involved in T follicular helper cell differentiation IMP
IMP: Inferred from mutant phenotype
23045607 MGI
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
23045607 MGI
involved in germinal center B cell differentiation IMP
IMP: Inferred from mutant phenotype
23045607 MGI
acts upstream of interleukin-10 production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of natural killer cell cytokine production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of natural killer cell differentiation IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
14764669 MGI
involved in positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
23045607 MGI
acts upstream of or within positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of natural killer cell cytokine production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
14764669 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
14764669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-21

Recombinant Il21 Proteins

Cat. No. Product Name Accession Purity
HY-P7078 IL-21 Protein, Mouse (129a.a) Q9ES17 (H18-S146) ≥95%
HY-P70643 IL-21 Protein, Mouse (122a.a) Q9ES17 (P25-S146) ≥95%
HY-P78149 IL-21 Protein, Mouse (Biotinylated, His-Avi) Q9ES17 (H18-S146) ≥95%
HY-P700199AF Animal-Free IL-21 Protein, Mouse (His) Q9ES17 (H18-S146) ≥95%
HY-P700294 IL-21 Protein, Mouse (His) Q9ES17 (P25-S146) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99687 Latikafusp Inhibitor 99.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162490 TF-S14 Inhibitor / Unkown
HY-RS06734 IL21 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06735 IL21R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il21 NCBI NCBI:59067
Canis familiaris Il21 NCBI NCBI:442935
Macaca fascicularis Il21 NCBI NCBI:102130762
Rattus norvegicus Il21 NCBI NCBI:365769