RPS21 - ribosomal protein S21 Gene

Homo sapiens

Also known as S21; HLDF

Gene ID: 6227 | Gene type: protein coding

About RPS21

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,387,103-62,388,520 (from NCBI)

This gene has 5 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in ovary (RPKM 530.1), bone marrow (RPKM 407.8) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS21 Products(1)

mRNA	Protein	Name
NM_001024.4	NP_001015.1	40S ribosomal protein S21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10079194	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS21 Protein Structure

Ribosomal_S21e

0
83 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S21

8.2 kDa differentiation factor

RPS21 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS21	P63220	RPSA	Homo sapiens	P08865	Anti Tag CoIP	33961781
Intra	RPS21	P63220	RPSA	Homo sapiens	P08865	Y2H Pooling	16169070
Intra	RPS21	P63220	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	RPS21	P63220	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	RPS21	P63220	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	RPS21	P63220	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	RPS21	P63220	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	RPS21	P63220	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tremor, Hereditary Essential, 2

ETM2	Essential Tremor 2
Essential Tremor, Hereditary, 2	Hereditary Essential Tremor 2
Tremor Hereditary Essential, 2

Lactase Deficiency, Congenital

Congenital Lactase Deficiency	Disaccharide Intolerance Ii
Congenital Alactasia	Congenital Alactasia Syndrome
Congenital Lactose Intolerance	Congenital Lactose Malabsorption
Hereditary Alactasia	Alactasia, Congenital
Cld	COLACD
Disaccharide Intolerance Type 2	Cld - [Congenital Lactase Deficiency]
Disaccharide Intolerance 2	Lactose Intolerance Of Newborn
Hereditary Lactase Deficiency

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12233	RPS21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPS21	VGNC	VGNC:34134
Rattus norvegicus	RPS21	RGD	RGD:2323583
Canis familiaris	RPS21	VGNC	VGNC:45735
Mus musculus	RPS21	MGD	MGI:1913731
Macaca mulatta	RPS21	VGNC	VGNC:98438

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