RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

Homo sapiens

Also known as R1; RR1; RIR1

Gene ID: 6240 | Gene type: protein coding

About RRM1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,094,685-4,138,932 (from NCBI)

This gene has 14 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in skin (RPKM 18.5), lymph node (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an Enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RRM1 Products(4)

mRNA	Protein	Name
NM_001033.5	NP_001024.1	ribonucleoside-diphosphate reductase large subunit isoform 1
NM_001318064.1	NP_001304993.1	ribonucleoside-diphosphate reductase large subunit isoform 2
NM_001318065.1	NP_001304994.1	ribonucleoside-diphosphate reductase large subunit isoform 3
NM_001330193.1	NP_001317122.1	ribonucleoside-diphosphate reductase large subunit isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17726094	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17726094	GOA
enables ribonucleoside-diphosphate reductase activity	IMP IMP: Inferred from mutant phenotype	21336276	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 2'-deoxyribonucleotide biosynthetic process	IDA IDA: Inferred from direct assay	16376858	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	11719458	GOA
involved in mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	17486094	GOA
involved in positive regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	11517226	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	24253041	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	10716435	GOA
involved in ribonucleoside diphosphate metabolic process	IDA IDA: Inferred from direct assay	16376858	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	18997010	GOA
part of ribonucleoside-diphosphate reductase complex	IPI IPI: Inferred from physical interaction	22632967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRM1 Protein Structure

ATP-cone

Ribonuc_red_lgN

Ribonuc_red_lgC

0
200
400
600
792 a.a.

Protein Preferred Names

Protein Names

ribonucleoside-diphosphate reductase large subunit

ribonucleoside-diphosphate reductase subunit M1

RRM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	Anti Tag CoIP	33961781
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	Anti Tag CoIP	28514442
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	GMS	21336276
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	GMS	17726094
Intra	RRM1	P23921	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	RRM1	P23921	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	RRM1	P23921	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	RRM1	P23921	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	28514442
Intra	RRM1	P23921	ARL5B	Homo sapiens	Q96KC2	Anti Tag CoIP	28514442
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	X-Ray Diffraction	21336276
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	Light Scattering	21336276
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	GMS	17726094
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	GMS	21336276
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	Y2H Array	25416956
Intra	RRM1	P23921	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	33961781
Intra	RRM1	P23921	ARL5B	Homo sapiens	Q96KC2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RRM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74591	RRM1 Protein, Human (sf9, His-GST)	P23921 (M1-S792)	≥95%

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta	IMD25
Immunodeficiency, Type 25

Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18	RP7
Retinitis Pigmentosa 7, Digenic Form	Retinitis Pigmentosa 7 And Digenic Form
Retinitis Pigmentosa 7, Digenic	LCA18
Retinitis Pigmentosa 7 Digenic

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153898	rTRD01	Inhibitor	≥97.0%	Unkown
HY-153736	NSC 194308		98.40%	Unkown
HY-RS12285	RRM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RRM1	VGNC	VGNC:34164
Rattus norvegicus	RRM1	RGD	RGD:1592569
Canis familiaris	RRM1	VGNC	VGNC:45760
Macaca mulatta	RRM1	VGNC	VGNC:76941
Mus musculus	RRM1	MGD	MGI:98180
Felis catus	RRM1	VGNC	VGNC:64775
Others	RRM1	NCBI

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