PPP2R5E - protein phosphatase 2 regulatory subunit B'epsilon Gene

Homo sapiens

Also known as B56E; B56epsilon

Gene ID: 5529 | Gene type: protein coding

About PPP2R5E

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,371,364-63,543,377 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 11.5), colon (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

PPP2R5E Products(6)

mRNA	Protein	Name
NM_001282179.3	NP_001269108.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a
NM_001282180.3	NP_001269109.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform b
NM_001282181.3	NP_001269110.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c
NM_001282182.3	NP_001269111.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c
NM_001354926.2	NP_001341855.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform d
NM_006246.5	NP_006237.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15380617	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R5E Protein Structure

B56

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

PP2A, B subunit, B' epsilon

PPP2R5E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R5E	Q16537	CHEK2	Homo sapiens	O96017	Pull Down	15380617
Intra	PPP2R5E	Q16537	PPP2R1A	Homo sapiens	P30153	Y2H	23555304
Intra	PPP2R5E	Q16537	PPP2R1B	Homo sapiens	P30154	Y2H	23555304
Intra	PPP2R5E	Q16537	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	PPP2R5E	Q16537	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	PPP2R5E	Q16537	RACGAP1	Homo sapiens	Q9H0H5	Y2H	18201571
Intra	PPP2R5E	Q16537	RACGAP1	Homo sapiens	Q9H0H5	Far-WB	18201571
Intra	PPP2R5E	Q16537	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	18201571
Intra	PPP2R5E	Q16537	DZIP1	Homo sapiens	Q86YF9	Anti Tag CoIP	21878643

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11022	PPP2R5E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP2R5E	VGNC	VGNC:104608
Canis familiaris	PPP2R5E	VGNC	VGNC:44917
Rattus norvegicus	PPP2R5E	RGD	RGD:1305657
Macaca mulatta	PPP2R5E	VGNC	VGNC:76381
Mus musculus	PPP2R5E	MGD	MGI:1349473
Bos taurus	PPP2R5E	VGNC	VGNC:33264

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