2. Gene
  3. SRSF5 - serine and arginine rich splicing factor 5 Gene

SRSF5 - serine and arginine rich splicing factor 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HRS; SFRS5; SRP40

Gene ID: 6430 | Gene type: protein coding

About SRSF5

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,767,142-69,772,005 (from NCBI)

This gene has 19 transcripts (splice variants), 204 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 175.0), skin (RPKM 153.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SRSF5 Products(4)

mRNA Protein Name
NM_001039465.2 NP_001034554.1 serine/arginine-rich splicing factor 5 isoform 1
NM_001320214.2 NP_001307143.1 serine/arginine-rich splicing factor 5 isoform 1
NM_001411040.1 NP_001397969.1 serine/arginine-rich splicing factor 5 isoform 2
NM_006925.5 NP_008856.2 serine/arginine-rich splicing factor 5 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12762840 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF5 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (6 - 67)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (110 - 175)

  • 0
  • 100
  • 200
  • 272 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 5

SR splicing factor 5

SRSF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SRSF5 Q13243 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra
SRSF5 Q13243 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Intra
SRSF5 Q13243 ZRSR2 Homo sapiens Q15696
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina
Aleutian Mink Disease

Aleutian Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13796 SRSF5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SRSF5 VGNC VGNC:52831
Felis catus SRSF5 VGNC VGNC:65697
Macaca mulatta SRSF5 VGNC VGNC:99245
Mus musculus SRSF5 MGD MGI:98287
Canis familiaris SRSF5 VGNC VGNC:51690
Rattus norvegicus SRSF5 RGD RGD:3664