2. Gene
  3. ZRSR2 - zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 Gene

ZRSR2 - zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as URP; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2

Gene ID: 8233 | Gene type: protein coding

About ZRSR2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,790,484-15,823,260 (from NCBI)

This gene has 6 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 77 phenotypes. Ubiquitous expression in lymph node (RPKM 3.8), spleen (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

ZRSR2 Products(1)

mRNA Protein Name
NM_005089.4 NP_005080.1 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables pre-mRNA 3'-splice site binding IDA
IDA: Inferred from direct assay
21041408 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9237760 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
9237760 GOA
involved in spliceosomal complex assembly IMP
IMP: Inferred from mutant phenotype
21041408 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZRSR2 Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (168 - 192)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (246 - 302)

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  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2

ZRSR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZRSR2 Q15696 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
ZRSR2 Q15696 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
ZRSR2 Q15696 REP15 Homo sapiens Q6BDI9
Y2H Array
32296183
Intra
ZRSR2 Q15696 REP15 Homo sapiens Q6BDI9
Validated Y2H
32296183
Intra
ZRSR2 Q15696 REP15 Homo sapiens Q6BDI9
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695
Anti Tag CoIP
33961781
Intra
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695
Anti Tag CoIP
28514442
Intra
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695
Y2H Array
32296183
Intra
ZRSR2 Q15696 ZRSR2P1 Homo sapiens Q15695
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra
ZRSR2 Q15696 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra
ZRSR2 Q15696 SSX2IP Homo sapiens Q9Y2D8
Anti Tag CoIP
33961781
Intra
ZRSR2 Q15696 CCNL1 Homo sapiens Q9UK58
Validated Y2H
32296183
Intra
ZRSR2 Q15696 CCNL1 Homo sapiens Q9UK58
Y2H Array
32296183
Intra
ZRSR2 Q15696 CCNL1 Homo sapiens Q9UK58
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 LUC7L2 Homo sapiens Q9Y383
Y2H Array
32296183
Intra
ZRSR2 Q15696 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
Intra
ZRSR2 Q15696 LUC7L2 Homo sapiens Q9Y383
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 SRRM4 Homo sapiens A7MD48
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 SRRM4 Homo sapiens A7MD48
Y2H Array
32296183
Intra
ZRSR2 Q15696 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra
ZRSR2 Q15696 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
28514442
Intra
ZRSR2 Q15696 SRPK2 Homo sapiens P78362
Y2H Prey Pooling
25416956
Intra
ZRSR2 Q15696 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra
ZRSR2 Q15696 SRPK2 Homo sapiens P78362
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Intra
ZRSR2 Q15696 SRPK2 Homo sapiens P78362
Y2H Array
32296183
Intra
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190
Y2H Array
32296183
Intra
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra
ZRSR2 Q15696 CLK2 Homo sapiens P49760
Validated Y2H
25416956
Intra
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra
ZRSR2 Q15696 CLK2 Homo sapiens P49760
Y2H Prey Pooling
25416956
Intra
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190
Validated Y2H
32296183
Intra
ZRSR2 Q15696 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
Intra
ZRSR2 Q15696 SRSF5 Homo sapiens Q13243
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 SRSF5 Homo sapiens Q13243
Y2H Array
32296183
Intra
ZRSR2 Q15696 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
ZRSR2 Q15696 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
ZRSR2 Q15696 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 CLK2 Homo sapiens P49760
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 CLK2 Homo sapiens P49760
Y2H Array
32296183
Intra
ZRSR2 Q15696 TNFAIP8L1 Homo sapiens Q8WVP5
Validated Y2H
32296183
Intra
ZRSR2 Q15696 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Array
32296183
Intra
ZRSR2 Q15696 KHDC4 Homo sapiens Q7Z7F0-4
Y2H Prey Pooling
32296183
Intra
ZRSR2 Q15696 KHDC4 Homo sapiens Q7Z7F0-4
Validated Y2H
32296183
Intra
ZRSR2 Q15696 KHDC4 Homo sapiens Q7Z7F0-4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Holoprosencephaly 1

Arhinencephaly

HPE1

Cyclopia

Holoprosencephaly, Familial Alobar

Hpe, Familial

Hpec

Demyer Sequence

Holoprosencephaly-1
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Vexas Syndrome

VEXAS

Vexas Syndrome, Somatic

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Chronic Leukemia

Adult Chronic Leukemia

Cll

Cml
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia

Atypical Chronic Myeloid Leukaemia

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Acml

Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Atypical Cml

Subacute Myeloid Leukemia

Subacute Myelogenous Leukaemia

Subacute Myeloid Leukaemia

Subacute Myelosis

Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission

Subacute Monocytic Leukaemia Without Mention Of Remission

Subacute Monocytic Leukaemia
Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome

Brachymelic Primordial Dwarfism

Cephaloskeletal Dysplasia

Low-Birth-Weight Dwarfism With Skeletal Dysplasia

Microcephalic Osteodysplastic Primordial Dwarfism Type I

Osteodysplastic Primordial Dwarfism Type I

Primordial Microcephalic Dwarfism, Crachami Type

Osteodysplastic Primordial Dwarfism, Type 1

MOPD1

Mopd I

Mopd

Osteodysplastic Primordial Dwarfism, Type I

Tals

Microcephalic Osteodysplastic Primordial Dwarfism Type 1

Mopd 1

Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

Mopd Types I And Iii

Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

Primordial Microcephalic Dwarfism Crachami Type

Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Myelodysplastic/Myeloproliferative Neoplasm

Myelodysplastic-Myeloproliferative Diseases

Myelodysplastic/Myeloproliferative Disease

Myelodysplastic Myeloproliferative Cancer

Myelodysplastic Myeloproliferative Disease

Myeloproliferative/Myelodysplastic Syndromes
Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic

Cmml

Leukemia Myelomonocytic Chronic

Cmml - [Chronic Myelomonocytic Leukaemia]

Chronic Myelomonocytic Leukaemia Without Mention Of Remission

Chronic Monocytic Leukaemia

Chronic Monocytoid Leukaemia
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential
Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16196 ZRSR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZRSR2 RGD RGD:1559763
Mus musculus ZRSR2 MGD MGI:103287