SRSF6 - serine and arginine rich splicing factor 6 Gene

Homo sapiens

Also known as B52; SFRS6; SRP55; HEL-S-91

Gene ID: 6431 | Gene type: protein coding

About SRSF6

Cytogenetic location: 20q13.11 Genomic coordinates (GRCh38): 20:43,457,896-43,464,243 (from NCBI)

This gene has 6 transcripts (splice variants), 260 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 64.4), prostate (RPKM 51.8) and 25 other tissues.

Summary

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the Other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

SRSF6 Products(1)

mRNA	Protein	Name
NM_006275.6	NP_006266.2	serine/arginine-rich splicing factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	24440982	GOA
enables pre-mRNA binding	IDA IDA: Inferred from direct assay	12549914	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	22767602	GOA
involved in mRNA splice site recognition	IMP IMP: Inferred from mutant phenotype	12549914	GOA
involved in negative regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	24440982	GOA
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15009664	GOA
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IDA IDA: Inferred from direct assay	23132731	GOA
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	23132731	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	24440982	GOA
involved in regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	24440982	GOA
involved in regulation of wound healing	IMP IMP: Inferred from mutant phenotype	24440982	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	22767602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF6 Protein Structure

RRM_1

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

serine/arginine-rich splicing factor 6

SR splicing factor 6

SRSF6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRSF6	Q13247	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	25416956
Intra	SRSF6	Q13247	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
Intra	SRSF6	Q13247	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	25416956
Intra	SRSF6	Q13247	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	31515488
Intra	SRSF6	Q13247	RNPS1	Homo sapiens	Q15287	Y2H Pooling	16189514
Intra	SRSF6	Q13247	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	SRSF6	Q13247	LUC7L	Homo sapiens	Q9NQ29-3	Validated Y2H	32296183
Intra	SRSF6	Q13247	SRSF4	Homo sapiens	Q08170	Y2H Array	31515488
Intra	SRSF6	Q13247	SRSF4	Homo sapiens	Q08170	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Plasmodium Malariae Malaria

Quartan Malaria	Malaria By Plasmodium Malariae
Nephrotic Syndrome Of Quartan Malaria	Malaria Nephrosis
Malarial Nephrosis	Nephrotic Syndrome In Malaria
Quartan Nephrosis

Aortitis

Cataract 30

Cataract 30 Pulverulent	Cataract Coppock-Like
Ctrct30	Dusty Cataract
Cataract, Type 30

Temporal Arteritis

Polymyalgia Rheumatica	Giant Cell Arteritis
Cranial Arteritis	Horton Disease
Gca	Horton'S Disease
Rhizomelic Pseudopolyarthritis	Arteritis Cranialis
Arteritis Temporalis	Horton'S Arteritis
Horton'S Giant Cell Arteritis	Horton'S Temporal Arteritis
Horton'S Syndrome	Gca - [Giant Cell Arteritis]
Senile Arthritis	Polymyalgia Arteritica
Pmr - [Polymyalgia Rheumatica]	Forestier-Certonciny Syndrome
Rheumatic Polymyalgia	Polymyalgia

Aortic Valve Insufficiency

Aortic Regurgitation	Rheumatic Aortic Regurgitation
Aortic Insufficiency	Rheumatic Aortic Insufficiency
Rheumatic Aortic Valve Insufficiency	Aortic Incompetence
Corrigan'S Disease	Rheumatic Aortic Valve Regurgitation
Aortic Valve Incompetency	Ai - [Aortic Incompetence]
Incompetent Aortic Valve	Ar - [Aortic Regurgitation]
Calcific Aortic Valve Regurgitation	Myxomatous Aortic Valve Regurgitation
Annular Incompetency Of Aortic Valve	Austin Flint Murmur
Flint Murmur	Rheumatic Aortic Incompetence
Rheumatic Ai - [Aortic Insufficiency]

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13797	SRSF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SRSF6	VGNC	VGNC:54735
Mus musculus	SRSF6	MGD	MGI:1915246
Rattus norvegicus	SRSF6	RGD	RGD:1359241
Bos taurus	SRSF6	VGNC	VGNC:57028
Macaca mulatta	SRSF6	VGNC	VGNC:77821

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