SLC2A5 - solute carrier family 2 member 5 Gene

Homo sapiens

Also known as GLUT5; GLUT-5

Gene ID: 6518 | Gene type: protein coding

About SLC2A5

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:9,035,106-9,094,195 (from NCBI)

This gene has 10 transcripts (splice variants), 259 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 33.7), small intestine (RPKM 25.5) and 8 other tissues.

Summary

The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]

SLC2A5 Products(5)

mRNA	Protein	Name
NM_001135585.2	NP_001129057.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 2
NM_001328619.2	NP_001315548.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 1
NM_001328620.2	NP_001315549.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 3
NM_001328621.2	NP_001315550.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 4
NM_003039.3	NP_003030.1	solute carrier family 2, facilitated glucose transporter member 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fructose transmembrane transporter activity	IDA IDA: Inferred from direct assay	8333543	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fructose import across plasma membrane	IDA IDA: Inferred from direct assay	8333543	GOA
involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	28083649	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8333543	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A5 Protein Structure

Sugar_tr

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 5

glucose transporter type 5, small intestine

Related Diseases

Diseases

Alias

Fructosuria, Essential

Essential Fructosuria	Ketohexokinase Deficiency
Fructosuria	Hepatic Fructokinase Deficiency
Fructokinase Deficiency	FRUCT
Deficiency Of Fructokinase

Lactase Deficiency, Congenital

Congenital Lactase Deficiency	Disaccharide Intolerance Ii
Congenital Alactasia	Congenital Alactasia Syndrome
Congenital Lactose Intolerance	Congenital Lactose Malabsorption
Hereditary Alactasia	Alactasia, Congenital
Cld	COLACD
Disaccharide Intolerance Type 2	Cld - [Congenital Lactase Deficiency]
Disaccharide Intolerance 2	Lactose Intolerance Of Newborn
Hereditary Lactase Deficiency

Osmotic Diarrhea

Lung Acinar Adenocarcinoma

Acinar Adenocarcinoma Of The Lung

Fructose Intolerance, Hereditary

Hereditary Fructose Intolerance	Fructose Intolerance
Fructose-1-Phosphate Aldolase Deficiency	Fructose-1,6-Bisphosphate Aldolase B Deficiency
Aldolase B Deficiency	Fructosemia
Aldob Deficiency	Hereditary Fructose Intolerance Syndrome
HFI	Fructosaemia
Hereditary Fructose-1-Phosphate Aldolase Deficiency	Fructose Aldolase B Deficiency
Fructose-1,6-Biphosphate Aldolase Deficiency	Hereditary Fructosemia
Fructosemia, Hereditary	Hereditary Fructosaemia
Fructose-Biphosphate Aldolase B Deficiency	Fructose Intolerance Of Newborn
Aldb - [Aldolase B] Deficiency	Deficiency Of Fructose-Bisphosphate Aldolase

Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency	CSID
Si Deficiency	Congenital Sucrose Intolerance
Disaccharide Intolerance	Sucrase-Isomaltase Deficiency
Disaccharide Intolerance I	Congenital Sucrose-Isomaltose Malabsorption
Sucrose-Isomaltose Malabsorption, Congenital	Sucrose Intolerance, Congenital
Congenital Sucrase-Isomaltose Malabsorption	Congenital Sucrose-Isomaltase Malabsorption
Disaccharide Intolerance, 1	Sucrose Intolerance Congenital
Sucrose-Isomaltase Malabsorption, Congenital	Disaccharidase Deficiency
Invertase Deficiency	Sucrase-Alpha-Dextrinase Deficiency
Disaccharide Intolerance Type I	Csid - [Congenital Sucrase-Isomaltase Deficiency]
Sucrose Intolerance Of Newborn	Sucrose Intolerance
Sucrase Deficiency	Disaccharide Malabsorption
Intestinal Disaccharidase Deficiency

Lactose Intolerance

Lactose Malabsorption	Lm - Lactose Malabsorption
Alactasia	Dairy Product Intolerance
Hypolactasia	Milk Sugar Intolerance
Cow Milk Enteropathy	Intolerance Or Malabsorption Of Lactose
Lm - [Lactose Malabsorption]	Milk Intolerance

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13174	SLC2A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC2A5	RGD	RGD:68328
Mus musculus	SLC2A5	MGD	MGI:1928369
Macaca mulatta	SLC2A5	VGNC	VGNC:77450
Others	SLC2A5	NCBI

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