SLC5A2 - solute carrier family 5 member 2 Gene

Homo sapiens

Also known as SGLT2

Gene ID: 6524 | Gene type: protein coding

About SLC5A2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,483,123-31,490,769 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues, 11 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 31.7), ovary (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]

SLC5A2 Products(4)

mRNA	Protein	Name
XM_024450402.2	XP_024306170.2	sodium/glucose cotransporter 2 isoform X2
XM_006721072.5	XP_006721135.3	sodium/glucose cotransporter 2 isoform X1
NM_003041.4	NP_003032.1	sodium/glucose cotransporter 2
NR_130783.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	20980548	GOA
enables D-glucose:sodium symporter activity	EXP EXP: Inferred from Experiment	11133510	GOA
enables D-glucose:sodium symporter activity	IDA IDA: Inferred from direct assay	20980548	GOA
enables alpha-glucoside transmembrane transporter activity	IDA IDA: Inferred from direct assay	20980548	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import across plasma membrane	IDA IDA: Inferred from direct assay	20980548	GOA
involved in alpha-glucoside transport	IDA IDA: Inferred from direct assay	20980548	GOA
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	20980548	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	26376857	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC5A2 Protein Structure

SSF

0
200
400
600
672 a.a.

Protein Preferred Names

Protein Names

sodium/glucose cotransporter 2

Na(+)/glucose cotransporter 2	low affinity sodium-glucose cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 2	solute carrier family 5 (sodium/glucose transporter), member 2

SLC5A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC5A2	P31639	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	33961781
Intra	SLC5A2	P31639	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	28514442
Intra	SLC5A2	P31639	PDZK1IP1	Homo sapiens	Q13113	TSA	38057552
Intra	SLC5A2	P31639	PDZK1IP1	Homo sapiens	Q13113	GMS	38057552

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi-Like Syndrome

Fanconi Like Syndrome

Chylomicron Retention Disease

CMRD	Anderson Disease
Lipid Transport Defect Of Intestine	Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells
Andd	Anderson Syndrome
Crd	Andersons Disease
Malabsorption Syndrome

Renal Glucosuria

Renal Glycosuria	Familial Renal Glucosuria
Glycosuria, Renal	GLYS
Glys1	Glucosuria, Renal
Renal Diabetes	Familial Renal Glycosuria
Sglt2 Deficiency	Gly
Diabetes Renal

Vulvitis

Vulvitis Nos	Inflammation Of Vulva
Edeitis

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diabetes Mellitus

Diabetes

Inherited Metabolic Disorder

Inborn Errors Of Metabolism	Inborn Metabolism Disorder
Metabolic Hereditary Disorder	Inborn Error Of Metabolism
Inborn Metabolic Disorder	Metabolism, Inborn Errors

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Pyelitis

Penile Disease

Penile Diseases

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1	Persistent Hyperinsulinemic Hypoglycemia Of Infancy
Familial Hyperinsulinemic Hypoglycemia 1	Congenital Hyperinsulinism
Phhi	Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Of Infancy	Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia
Nesidioblastosis Of Pancreas	Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis
Hyperinsulinism, Congenital	Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form
Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency	Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Balanoposthitis

Balanitis Due To Infection

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Pancreatic Colloid Cystadenoma

Mucinous Cystadenoma Of Pancreas

Hyperglycemia

Alcoholic Ketoacidosis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism	Disorder Of Carbohydrate Metabolism
Carbohydrate Metabolism, Inborn Errors	Disorder Of Carbohydrate Transport And Metabolism
Inborn Carbohydrate Metabolism Disorder	Inborn Carbohydrate Metabolic Disorder
Carbohydrate Metabolism Disorder	Carbohydrate Metabolism Disorders
Disorders Of Carbohydrate Metabolism	Congenital Disorders Of Carbohydrate Metabolism
Inherited Disorders Of Carbohydrate Metabolism

Aminoaciduria

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Autoimmune Disease Of Endocrine System

Silent Myocardial Infarction

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Vulvovaginitis

Vulvo-Vaginitis

Kidney Hypertrophy

Hypertrophy Of Kidney

Intermediate Coronary Syndrome

Unstable Angina	Angina At Rest
Anginal Chest Pain At Rest	Impending Infarction
Preinfarction Angina	Worsening Angina
Angina, Unstable	Myocardial Preinfarction Syndrome
Angina Unstable	Crescendo Angina
Angina Decubitus	Acute Coronary Insufficiency
Unstable Angina Pectoris	Preinfarctional Angina Pectoris
Worsening Effort Angina	Preinfarction Syndrome
Unstable Angina Pectoris Syndrome	Unstable Anginal Attack
Unstable Cardiac Angina	Unstable Chest Angina
Unstable Heart Angina	De Novo Effort Angina Pectoris
Crescendo Angina Pectoris	Ua - [Unstable Angina]

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Balanitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13286	SLC5A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13287	Slc5a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13288	Slc5a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC5A2	MGD	MGI:2181411
Felis catus	SLC5A2	VGNC	VGNC:65402
Bos taurus	SLC5A2	VGNC	VGNC:34906
Canis familiaris	SLC5A2	VGNC	VGNC:46446
Macaca mulatta	SLC5A2	VGNC	VGNC:77610
Rattus norvegicus	SLC5A2	RGD	RGD:620217