2. Gene
  3. BMX - BMX non-receptor tyrosine kinase Gene

BMX - BMX non-receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ETK; PSCTK2; PSCTK3

Gene ID: 660 | Gene type: protein coding

About BMX

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,500,807-15,556,519 (from NCBI)

This gene has 5 transcripts (splice variants), 137 orthologues and 32 paralogues. Broad expression in bone marrow (RPKM 2.4), placenta (RPKM 2.2) and 21 other tissues.

Summary

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the STAT pathway, and regulates differentiation and tumorigenicity of several types of Cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

BMX Products(4)

mRNA Protein Name
NM_203281.3 NP_975010.1 cytoplasmic tyrosine-protein kinase BMX isoform 1
NM_001320866.2 NP_001307795.1 cytoplasmic tyrosine-protein kinase BMX isoform 2
XM_017029752.3 XP_016885241.1 cytoplasmic tyrosine-protein kinase BMX isoform X1
NM_001721.7 NP_001712.1 cytoplasmic tyrosine-protein kinase BMX isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10688651 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10688651 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11331870 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
10688651 GOA
Cellular Component GO Annotation Evidence Reference Source
located in ruffle membrane IDA
IDA: Inferred from direct assay
11331870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMX Protein Structure

PH

PH: PH domain (6 - 110)

BTK

BTK: BTK motif (119 - 148)

SH2

SH2: SH2 domain (296 - 377)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (417 - 665)

  • 0
  • 200
  • 400
  • 600
  • 675 a.a.
Protein Preferred Names Protein Names

cytoplasmic tyrosine-protein kinase BMX

BTK-like on X chromosome

Etk/Bmx cytosolic tyrosine kinase

NTK38 tyrosine kinase

bone marrow tyrosine kinase gene in chromosome X protein

epithelial and endothelial tyrosine kinase

BMX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BMX P51813 PIM1 Homo sapiens P11309-2
Anti Bait CoIP
16186805
Intra
BMX P51813 PTPN21 Homo sapiens Q16825
Y2H Array
32296183
Intra
BMX P51813 PTPN21 Homo sapiens Q16825
Y2H Prey Pooling
32296183
Intra
BMX P51813 PTPN21 Homo sapiens Q16825
Validated Y2H
32296183
Intra
BMX P51813 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
BMX P51813 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra
BMX P51813 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
BMX P51813 BIRC2 Homo sapiens Q13490
Validated Y2H
32296183
Intra
BMX P51813 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra
BMX P51813 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
25416956
Intra
BMX P51813 STAT3 Homo sapiens P40763
Validated Y2H
25416956
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
31515488
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Prey Pooling
32296183
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Prey Pooling
25416956
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
25814554
Intra
BMX P51813 STAT3 Homo sapiens P40763
Y2H Array
32296183
Intra
BMX P51813 PIM1 Homo sapiens P11309
Anti Bait CoIP
16186805
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wet Beriberi
Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia

XLA

Bruton Type Agammaglobulinemia

Bruton'S Agammaglobulinemia

Bruton-Type Agammaglobulinemia

Agmx1

Imd1

Agammaglobulinemia, X-Linked 1

Btk-Deficiency

Agammaglobulinemia

Hypogammaglobulinemia

Agammaglobulinemia, X-Linked, Type 1

Immunodeficiency 1

Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

Bruton'S Agammaglobulinaemia

Bruton'S Sex-Linked Agammaglobulinemia

Bruton'S Type Agammaglobulinemia

Btk Deficiency

Agammaglobulinemia, Btk

Agammaglobulinemia, Bruton Tyrosine Kinase

Congenital Agammaglobulinemia

Immunodeficiency Type 1

X-Linked Agammaglobulinemia Type 1
Integrative Agnosia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Thiamine Deficiency Disease
Beriberi

Thiamine Deficiency

Vitamin B1 Deficiency

Aneurin Deficiency

Thiamine Vitamin Deficiency

Beriberi Nos

Beriberi Due To Vitamin B1 Deficiency

Beriberi Due To Thiamine Vitamin Deficiency

Kakkè
Cardiomyopathy, Dilated, 1gg

Dilated Cardiomyopathy 1gg

CMD1GG

Cardiomyopathy, Dilated 1gg

Cardiomyopathy, Dilated, Type 1gg
Agammaglobulinemia

Hypogammaglobulinemia

Ighm

Mu Heavy Chain Deficiency

Mu-Heavy Chain Disease

Mu-Hcd

Mu-Chain Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-130574 MnTE-2-PyP chloride ≥95.0% Phase 2
HY-111553 TAS0728 Inhibitor 99.15% Phase 1
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80002 BMX-IN-1 Inhibitor 99.04% Unkown
HY-101267 CHMFL-BMX-078 Inhibitor ≥98.0% Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-RS01557 BMX Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01558 Bmx Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01559 Bmx Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-125662A BMX-001 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BMX RGD RGD:1565643
Canis familiaris BMX VGNC VGNC:38489
Felis catus BMX VGNC VGNC:60140
Mus musculus BMX MGD MGI:1101778
Bos taurus BMX VGNC VGNC:26529
Macaca mulatta BMX VGNC VGNC:70269
Others BMX NCBI