PTPN21 - protein tyrosine phosphatase non-receptor type 21 Gene

Homo sapiens

Also known as PTPD1; PTPRL10

Gene ID: 11099 | Gene type: protein coding

About PTPN21

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:88,465,778-88,555,007 (from NCBI)

This gene has 9 transcripts (splice variants), 220 orthologues and 35 paralogues. Broad expression in thyroid (RPKM 8.6), lung (RPKM 8.5) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX Kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

PTPN21 Products(1)

mRNA	Protein	Name
NM_007039.4	NP_008970.2	tyrosine-protein phosphatase non-receptor type 21

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15143158	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN21 Protein Structure

FERM_N

FERM_M

FERM_C

Y_phosphatase

0
200
400
600
800
1000
1174 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 21

dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)

PTPN21 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN21	Q16825	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
Intra	PTPN21	Q16825	PARD6A	Homo sapiens	Q9NPB6-2	Validated Y2H	32296183
Intra	PTPN21	Q16825	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	PTPN21	Q16825	NSMF	Homo sapiens	Q6X4W1-2	Validated Y2H	32296183
Intra	PTPN21	Q16825	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	PTPN21	Q16825	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	PTPN21	Q16825	FBXO17	Homo sapiens	Q96EF6	Validated Y2H	32296183
Intra	PTPN21	Q16825	TRIM14	Homo sapiens	Q14142	Y2H Array	32296183
Intra	PTPN21	Q16825	TRIM14	Homo sapiens	Q14142	Y2H Prey Pooling	32296183
Intra	PTPN21	Q16825	SNX18	Homo sapiens	Q96RF0	Validated Y2H	32296183
Intra	PTPN21	Q16825	CWC22	Homo sapiens	Q9HCG8	Validated Y2H	32296183
Intra	PTPN21	Q16825	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	PTPN21	Q16825	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	PTPN21	Q16825	SRC	Homo sapiens	P12931	Anti Bait CoIP	15143158
Intra	PTPN21	Q16825	RASD1	Homo sapiens	Q9Y272	Validated Y2H	32296183
Intra	PTPN21	Q16825	PAK5	Homo sapiens	Q9P286	Y2H Array	32296183
Intra	PTPN21	Q16825	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	32296183
Intra	PTPN21	Q16825	PAK5	Homo sapiens	Q9P286	Validated Y2H	32296183
Intra	PTPN21	Q16825	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	PTPN21	Q16825	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	PTPN21	Q16825	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	32296183
Cross	PTPN21	Q16825	Akap1	Mus musculus	O08715-5	Pull Down	15143158
Cross	PTPN21	Q16825	Akap1	Mus musculus	O08715-5	Anti Tag CoIP	15143158
Intra	PTPN21	Q16825	MOB3C	Homo sapiens	Q70IA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Toxic Diffuse Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153446	Tegeprotafib	Inhibitor	99.30%	Unkown
HY-153638	PTPN2/1-IN-2	Antagonist	99.56%	Unkown
HY-162428	PTPN2/1-IN-3	Inhibitor	/	Unkown
HY-RS11423	PTPN21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPN21	VGNC	VGNC:45174
Felis catus	PTPN21	VGNC	VGNC:69162
Mus musculus	PTPN21	MGD	MGI:1344406
Macaca mulatta	PTPN21	VGNC	VGNC:76602
Bos taurus	PTPN21	VGNC	VGNC:33535
Rattus norvegicus	PTPN21	RGD	RGD:620216

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