SNRPE - small nuclear ribonucleoprotein polypeptide E Gene

Homo sapiens

Also known as SME; Sm-E; HYPT11; snRNP-E

Gene ID: 6635 | Gene type: protein coding

About SNRPE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,861,599-203,871,152 (from NCBI)

This gene has 6 transcripts (splice variants), 178 orthologues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 16.8), ovary (RPKM 16.5) and 25 other tissues.

Summary

The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

SNRPE Products(4)

mRNA	Protein	Name
NM_001304464.2	NP_001291393.1	small nuclear ribonucleoprotein E isoform 2
NM_001328637.2	NP_001315566.1	small nuclear ribonucleoprotein E isoform 3
NM_001328638.2	NP_001315567.1	small nuclear ribonucleoprotein E isoform 4
NM_003094.4	NP_003085.1	small nuclear ribonucleoprotein E isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9417867	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U4 snRNP	IDA IDA: Inferred from direct assay	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	18984161	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23246290	GOA
part of pICln-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPE Protein Structure

LSM

0
92 a.a.

Protein Preferred Names

Protein Names

small nuclear ribonucleoprotein E

sm protein E

SNRPE Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNRPE	P62304	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Validated Y2H	32296183
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H Array	32296183
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Comig Non-Denat Gel	18984161
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H	9417867
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H Prey Pooling	32296183
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	Y2H	22365833
Intra	SNRPE	P62304	SNRPF	Homo sapiens	P62306	GMS	18984161
Intra	SNRPE	P62304	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	SNRPE	P62304	LSM5	Homo sapiens	Q9Y4Y9	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	GEMIN5	Homo sapiens	Q8TEQ6	Anti Tag CoIP	28514442
Intra	SNRPE	P62304	GEMIN5	Homo sapiens	Q8TEQ6	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Validated Y2H	32296183
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	GMS	18984161
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Comig Non-Denat Gel	18984161
Intra	SNRPE	P62304	SNRPG	Homo sapiens	P62308	Y2H	9417867
Intra	SNRPE	P62304	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	33961781
Intra	SNRPE	P62304	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypotrichosis 11

HYPT11

Hypotrichosis, Type 11

Hypotrichosis Simplex

Hereditary Hypotrichosis Simplex

Hhs

Hypotrichosis

Hypotrichosis 7

Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis	HYPT7
Hypotrichosis, Localized, Autosomal Recessive 2	Lah2
Ah	Total Hypotrichosis, Mari Type
Wh/Ht	Hypotrichosis, Autosomal Recessive
Hypotrichosis, Total, Mari Type	Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis
Total Mari Type Hypotrichosis	Alopecia Universalis Congenita, Mari Type
Mari Type Alopecia Universalis Congenita	Autosomal Recessive Hypotrichosis
Autosomal Recessive Localized Hypotrichosis	Autosomal Recessive Woolly Hair With Or Without Hypotrichosis
Htl	Hypotrichoses
Hypotrichosis	Lah
Alopecia Universalis Congenita Mari Type	Hypotrichosis Autosomal Recessive
Hypotrichosis Localized Autosomal Recessive 2	Total Hypotrichosis Mari Type
Woolly Hair Autosomal Recessive 2	ARWH2
Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Hypotrichosis 4

HYPT4	Marie Unna Hereditary Hypotrichosis 1
Muhh1	Hypotrichosis, Marie Unna Type, 1
Hypotrichosis Marie Unna 1	Marie Unna Hereditary Hypotrichosis Type 1
Hypotrichosis, Hereditary, Marie Unna Type, 1	Hypotrichosis, Type 4

Hypotrichosis 6

HYPT6	Lah1
Hypotrichosis, Localized, Autosomal Recessive	Monilethrix-Like Hypotrichosis
Hypotrichosis, Localized, Autosomal Recessive 1	Lah
Htl	Autosomal Recessive Localized Hypotrichosis
Hypotrichosis Localized Autosomal Recessive	Hypotrichosis Localized Autosomal Recessive 1
Hypotrichosis, Type 6

Hypotrichosis 8

HYPT8	Lah3
Hypotrichosis, Localized, Autosomal Recessive 3	Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis
Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis	Hypotrichosis Localized Autosomal Recessive 3
Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis	ARWH1
Hypotrichosis, Type 8

Hypotrichosis 13

HYPT13	Hypotrichosis With Woolly Hair
Hypotrichosis, Type 13

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Alopecia, Neurologic Defects, And Endocrinopathy Syndrome

Ane Syndrome	ANES
Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome	Alopecia-Progressive Neurological Defect-Endocrinopathy
Endocrine System Diseases

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13508	SNRPE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNRPE	MGD	MGI:98346
Rattus norvegicus	SNRPE	RGD	RGD:2321675
Macaca mulatta	SNRPE	VGNC	VGNC:100145

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