2. Gene
  3. LSM5 - LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

LSM5 - LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as YER146W

Gene ID: 23658 | Gene type: protein coding

About LSM5

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:32,485,338-32,495,283 (from NCBI)

This gene has 10 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in thyroid (RPKM 6.1), colon (RPKM 6.1) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM5 Products(3)

mRNA Protein Name
NM_001130710.2 NP_001124182.1 U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_001139499.2 NP_001132971.1 U6 snRNA-associated Sm-like protein LSm5 isoform b
NM_012322.3 NP_036454.1 U6 snRNA-associated Sm-like protein LSm5 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15231747 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
12515382 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within mRNA catabolic process IDA
IDA: Inferred from direct assay
12515382 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Lsm2-8 complex IDA
IDA: Inferred from direct assay
10523320 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12515382 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26912367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM5 Protein Structure

LSM

LSM: LSM domain (18 - 84)

  • 0
  • 91 a.a.
Protein Preferred Names Protein Names

U6 snRNA-associated Sm-like protein LSm5

LSM5 U6 small nuclear RNA and mRNA degradation associated

LSM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra LSM5 Q9Y4Y9 SPMIP10 Homo sapiens Q6ZNM6
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 SPMIP10 Homo sapiens Q6ZNM6
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 SNRPE Homo sapiens P62304
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 SNRPE Homo sapiens P62304
Y2H
15231747
Intra LSM5 Q9Y4Y9 SNRPE Homo sapiens P62304
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Y2H
15231747
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Anti Tag CoIP
33961781
Intra LSM5 Q9Y4Y9 LSM3 Homo sapiens P62310
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Prey Pooling
25416956
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H
15231747
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Array
31515488
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Validated Y2H
25416956
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H
22365833
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Y2H Array
25416956
Intra LSM5 Q9Y4Y9 LSM7 Homo sapiens Q9UK45
Anti Tag CoIP
33961781
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H
22365833
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Anti Tag CoIP
33961781
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H
15231747
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 SNRPF Homo sapiens P62306
Validated Y2H
25416956
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H Array
25416956
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H
15231747
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 LSM6 Homo sapiens P62312
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 TBPL1 Homo sapiens P62380
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 TBPL1 Homo sapiens P62380
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 TCL1B Homo sapiens O95988
Y2H Array
32296183
Intra LSM5 Q9Y4Y9 TCL1B Homo sapiens O95988
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra LSM5 Q9Y4Y9 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07860 LSM5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LSM5 RGD RGD:1308655
Felis catus LSM5 VGNC VGNC:80617
Macaca mulatta LSM5 VGNC VGNC:108418
Mus musculus LSM5 MGD MGI:1913623
Bos taurus LSM5 VGNC VGNC:31057