SNX2 - sorting nexin 2 Gene

Homo sapiens

Also known as TRG-9

Gene ID: 6643 | Gene type: protein coding

About SNX2

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:122,774,996-122,834,543 (from NCBI)

This gene has 13 transcripts (splice variants), 214 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 17.2), spleen (RPKM 14.1) and 25 other tissues.

Summary

This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

SNX2 Products(2)

mRNA	Protein	Name
NM_001278199.1	NP_001265128.1	sorting nexin-2 isoform 2
NM_003100.4	NP_003091.2	sorting nexin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9819414	GOA
enables insulin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables leptin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9819414	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11102511	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11102511	GOA
enables transferrin receptor binding	IDA IDA: Inferred from direct assay	9819414	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lamellipodium morphogenesis	IDA IDA: Inferred from direct assay	20604901	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	20138391	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11279102	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	15673616	GOA
located in membrane	IDA IDA: Inferred from direct assay	9819414	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	9819414	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer, tubulation complex	IPI IPI: Inferred from physical interaction	11102511	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX2 Protein Structure

Sorting_nexin

Vps5

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

sorting nexin-2

CTB-36H16.2

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101800	Senexin B	Inhibitor	99.72%	Unkown
HY-RS13533	SNX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117988	SNX2-1-108		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SNX2	VGNC	VGNC:65550
Rattus norvegicus	SNX2	RGD	RGD:1310291
Canis familiaris	SNX2	VGNC	VGNC:46629
Macaca mulatta	SNX2	VGNC	VGNC:77682
Mus musculus	SNX2	MGD	MGI:1915054
Bos taurus	SNX2	VGNC	VGNC:35100

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