2. Gene
  3. AURKC - aurora kinase C Gene

AURKC - aurora kinase C Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C

Gene ID: 6795 | Gene type: protein coding

About AURKC

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,231,023-57,235,548 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue.

Summary

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several Cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

AURKC Products(4)

mRNA Protein Name
NM_001015878.2 NP_001015878.1 aurora kinase C isoform 1
NM_001015879.2 NP_001015879.1 aurora kinase C isoform 2
NM_003160.3 NP_003151.2 aurora kinase C isoform 3
XM_047439253.1 XP_047295209.1 aurora kinase C isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
15670791 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15670791 GOA
Cellular Component GO Annotation Evidence Reference Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
15670791 GOA
located in midbody IDA
IDA: Inferred from direct assay
15670791 GOA
located in spindle midzone IDA
IDA: Inferred from direct assay
15670791 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKC Protein Structure

Pkinase

Pkinase: Protein kinase domain (43 - 293)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

aurora kinase C

ARK-3

aurora 3

aurora-related kinase 3

aurora/IPL1-related kinase 3

aurora/IPL1/EG2 protein 2

epididymis secretory protein Li 90

serine/threonine kinase 13 (aurora/IPL1-like)

serine/threonine-protein kinase 13

serine/threonine-protein kinase aurora-C

Related Diseases

Diseases Alias
Male Infertility With Spermatogenesis Disorder
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Nystagmus 3, Congenital, Autosomal Dominant

NYS3

Congenital Nystagmus 3

Autosomal Dominant Congenital Nystagmus 3
Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence
Infertility
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Prostate Carcinoma In Situ

Carcinoma In Situ Of Prostate

Grade Iii Pin

Pin Iii
Spermatogenic Failure 5

Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

SPGF5

Macrocephalic Sperm Head Syndrome

Male Infertility Due To Macrozoospermia

Infertility Associated With Multitailed Spermatozoa And Excessive Dna

Macrozoospermia

Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

Large-Headed Multiflagellar Polyploid Spermatozoa

Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123610 BRD-7880 Inhibitor / Unkown
HY-160691 GW814408X / Unkown
HY-RS01273 AURKC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01274 Aurkc Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01275 AURKC Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-119948 AKCI Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AURKC VGNC VGNC:70051
Mus musculus AURKC MGD MGI:1321119
Felis catus AURKC VGNC VGNC:60045
Rattus norvegicus AURKC RGD RGD:1309573
Canis familiaris AURKC VGNC VGNC:38313
Others AURKC NCBI