SUPT5H - SPT5 homolog, DSIF elongation factor subunit Gene

Homo sapiens

Also known as SPT5; SPT5H; Tat-CT1

Gene ID: 6829 | Gene type: protein coding

About SUPT5H

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,445,582-39,476,670 (from NCBI)

This gene has 20 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 64.5), bone marrow (RPKM 32.4) and 25 other tissues.

Summary

Enables Enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II promoter. Located in nucleoplasm. Part of DSIF complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT5H Products(12)

mRNA	Protein	Name
NM_001111020.3	NP_001104490.1	transcription elongation factor SPT5 isoform a
NM_001130824.2	NP_001124296.1	transcription elongation factor SPT5 isoform a
NM_001130825.2	NP_001124297.1	transcription elongation factor SPT5 isoform b
NM_001319990.2	NP_001306919.1	transcription elongation factor SPT5 isoform a
NM_001319991.2	NP_001306920.1	transcription elongation factor SPT5 isoform b
NM_003169.4	NP_003160.2	transcription elongation factor SPT5 isoform a
NM_001111020.3	NP_001104490.1	transcription elongation factor SPT5 isoform a
NM_001130824.2	NP_001124296.1	transcription elongation factor SPT5 isoform a
NM_001130825.2	NP_001124297.1	transcription elongation factor SPT5 isoform b
NM_001319990.2	NP_001306919.1	transcription elongation factor SPT5 isoform a
NM_001319991.2	NP_001306920.1	transcription elongation factor SPT5 isoform b
NM_003169.4	NP_003160.2	transcription elongation factor SPT5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	10075709	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10075709	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9450929	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	9450929	GOA
involved in negative regulation of DNA-templated transcription, elongation	IMP IMP: Inferred from mutant phenotype	10075709	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10075709	GOA
involved in positive regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	9450929	GOA
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10075709	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DSIF complex	IDA IDA: Inferred from direct assay	9450929	GOA
part of DSIF complex	IPI IPI: Inferred from physical interaction	19860741	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9450929	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT5H Protein Structure

Spt5_N

Spt5-NGN

KOW

CTD

0
200
400
600
800
1000
1087 a.a.

Protein Preferred Names

Protein Names

transcription elongation factor SPT5

DRB sensitivity-inducing factor 160 kDa subunit

SUPT5H Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Far-WB	10075709
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	MAPPIT	25416956
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	10075709
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	26496610
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	35271311
Intra	SUPT5H	O00267	PPIA	Homo sapiens	P62937	Pull Down	16169070
Intra	SUPT5H	O00267	PPIA	Homo sapiens	P62937	Y2H Pooling	16169070
Intra	SUPT5H	O00267	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SUPT5H	O00267	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Anti Tag CoIP	35271311
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	BFG-2H	27107012
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	TAP	24981860
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Anti Tag CoIP	26496610
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Crosslink	26789250
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Pull Down	10075709
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Y2H Array	31515488
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	MAPPIT	25416956
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	GMS	17404243
Cross	SUPT5H	O00267	POLR2B	Bos taurus	A5PJW8	Crosslink	26789250
Cross	SUPT5H	O00267	PA	Influenza A virus	Q5EP34	Anti Tag CoIP	21715506
Cross	SUPT5H	O00267	POLR2A	Bos taurus	G3MZY8	Crosslink	26789250

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm	Hyper Igm Syndrome
HIGM1	Xhim
Hyper-Igm Syndrome	Higm
Hyper-Igm Syndrome 1	Immunodeficiency 3
Imd3	Immunodeficiency With Hyper-Igm
Immunodeficiency With Hyper Igm Type 1	Ihis
X-Linked Hyper Igm Syndrome	Hyper-Igm Immunodeficiency, X-Linked
Hyper Igm Immunodeficiency, X-Linked	Hyper Igm Syndrome 1
X-Linked Immunodeficiency With Hyper-Igm 1	Immunodeficiency, With Hyper Igm
Immunodeficiency, With Hyper Igm, Type 1	Hyper-Igm Immunodeficiency Syndrome, Type 1
Hyperimmunoglobulin M Syndrome

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14038	SUPT5H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SUPT5H	VGNC	VGNC:46992
Mus musculus	SUPT5H	MGD	MGI:1202400
Felis catus	SUPT5H	VGNC	VGNC:65849
Macaca mulatta	SUPT5H	VGNC	VGNC:78056
Bos taurus	SUPT5H	VGNC	VGNC:35481
Rattus norvegicus	SUPT5H	RGD	RGD:1563807

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