TAL1 - TAL bHLH transcription factor 1, erythroid differentiation factor Gene

Homo sapiens

Also known as SCL; TCL5; tal-1; bHLHa17

Gene ID: 6886 | Gene type: protein coding

About TAL1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,216,290-47,232,335 (from NCBI)

This gene has 6 transcripts (splice variants), 212 orthologues, 4 paralogues and is associated with 61 phenotypes. Broad expression in bone marrow (RPKM 7.9), fat (RPKM 4.0) and 18 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022]

TAL1 Products(6)

mRNA	Protein	Name
NM_001287347.2	NP_001274276.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290403.2	NP_001277332.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290404.1	NP_001277333.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290405.1	NP_001277334.1	T-cell acute lymphocytic leukemia protein 1 isoform 1
NM_001290406.2	NP_001277335.1	T-cell acute lymphocytic leukemia protein 1 isoform 2
NM_003189.5	NP_003180.1	T-cell acute lymphocytic leukemia protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19497860	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	20855495	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15920471	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	16763211	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19497860	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	19497860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7568177	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in basophil differentiation	IEP IEP: Inferred from expression pattern	7678994	GOA
involved in erythrocyte differentiation	IEP IEP: Inferred from expression pattern	7678994	GOA
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	1396592	GOA
involved in megakaryocyte differentiation	IEP IEP: Inferred from expression pattern	7678994	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20028976	GOA
involved in positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of chromatin organization	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	20028976	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20855495	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	20855495	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20855495	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20855495	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19497860	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15920471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAL1 Protein Structure

HLH

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

T-cell acute lymphocytic leukemia protein 1

T-cell acute lymphocytic leukemia 1

Related Diseases

Diseases

Alias

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia	Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia
T-Cell Childhood Acute Lymphocytic Leukemia	Childhood T Lymphoblastic Leukemia/Lymphoma

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Erythroleukemia

Acute Leukemia

Stem Cell Leukaemia	Stem Cell Leukemia
Acute Leukemias	Acute Undifferentiated Leukemia
Undifferentiated Leukemia	Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission
Blast Cell Leukaemia	Blast Leukaemia
Blastic Leukaemia	Undifferentiated Leukaemia

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136522	S2116		98.15%	Unkown
HY-136523	S2157		98.44%	Unkown
HY-RS14189	TAL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAL1	MGD	MGI:98480
Rattus norvegicus	TAL1	RGD	RGD:1306748
Bos taurus	TAL1	VGNC	VGNC:35588
Canis familiaris	TAL1	VGNC	VGNC:47096

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