THRA - thyroid hormone receptor alpha Gene

Homo sapiens

Also known as AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; c-erbA; ERB-T-1; TRalpha; THRalpha; TRalpha1; TRalpha2; c-ERBA-1; THRalpha1; THRalpha2

Gene ID: 7067 | Gene type: protein coding

About THRA

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,062,193-40,093,867 (from NCBI)

This gene has 10 transcripts (splice variants), 460 orthologues, 18 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 66.6), ovary (RPKM 38.9) and 23 other tissues.

Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

THRA Products(4)

mRNA	Protein	Name
NM_001190918.2	NP_001177847.1	thyroid hormone receptor alpha isoform 3
NM_001190919.2	NP_001177848.1	thyroid hormone receptor alpha isoform 2
NM_003250.6	NP_003241.2	thyroid hormone receptor alpha isoform 2
NM_199334.5	NP_955366.1	thyroid hormone receptor alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8710870	GOA
enables TBP-class protein binding	IDA IDA: Inferred from direct assay	8524305	GOA
enables general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	8524305	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	8710870	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables thyroid hormone binding	IDA IDA: Inferred from direct assay	8710870	GOA
enables thyroid hormone binding	IPI IPI: Inferred from physical interaction	2879243	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18052923	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	18052923	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1310350	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8710870	GOA
involved in negative regulation of DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	8524305	GOA
involved in negative regulation of RNA polymerase II transcription preinitiation complex assembly	IDA IDA: Inferred from direct assay	8524305	GOA
involved in positive regulation of thyroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	1310350	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1310350	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18052923	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8710870	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	22474364	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19158403	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8710870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THRA Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

thyroid hormone receptor alpha

EAR-7

THRA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	THRA	P10827	SYAP1	Homo sapiens	Q96A49	Validated Y2H	32296183
Intra	THRA	P10827	SYAP1	Homo sapiens	Q96A49	Y2H Array	32296183
Intra	THRA	P10827	SYAP1	Homo sapiens	Q96A49	Y2H Prey Pooling	32296183
Intra	THRA	P10827	TACC1	Homo sapiens	O75410-7	Y2H Array	32296183
Intra	THRA	P10827	TACC1	Homo sapiens	O75410-7	Y2H Prey Pooling	32296183
Intra	THRA	P10827	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	THRA	P10827	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	THRA	P10827	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	THRA	P10827	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
Intra	THRA	P10827	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	THRA	P10827	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	THRA	P10827	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	THRA	P10827	MED1	Homo sapiens	Q15648	Far-WB	9653119
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Y2H	21516116
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	THRA	P10827	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	THRA	P10827	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Cross	THRA	P10827	Ncoa6	Rattus norvegicus	Q9JLI4	Y2H	10866662
Cross	THRA	P10827	Ncoa6	Rattus norvegicus	Q9JLI4	Pull Down	10866662

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypothyroidism, Congenital, Nongoitrous, 6

CHNG6	Congenital Nongoitrous Hypothyroidism 6
Hypothyroidism, Congenital, Non-Goitrous, 6	Hypothyroidism, Congenital, Nongoitrous, Type 6

Resistance To Thyroid Hormone Due To A Mutation In Thyroid Hormone Receptor Alpha

Rtha	Resistance To Thyroid Hormone Alpha
Resistance To Thyroid Hormone Due To A Mutation In Tra

Hyperthyroxinemia

Bone Giant Cell Tumor

Giant Cell Tumor Of Bone	Osteoclastoma
Gct Of Bone	Bone Giant Cell Tumour
Giant Cell Myeloma	Giant Cell Neoplasm Of Bone
Giant Cell Tumour Of Bone

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Thyroid Hormone Resistance, Generalized, Autosomal Dominant

Thyroid Hormone Resistance Syndrome	Thyroid Hormone Resistance
GRTHD	Gthr
Thyroid Hormone Unresponsiveness	Generalized Thyroid Hormone Resistance
Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Thyroid Hormones	Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones
Refetoff Syndrome	Thyroid Hormone Responsiveness Defect
Familial Euthyroid Hyperthyroxinemia, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones	Thyroid Hormone Resistance, Generalized, Autosomal Recessive

Erythroleukemia

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Neonatal Thyrotoxicosis

Thyroid Hormone Resistance, Selective Pituitary

PRTH	Selective Pituitary Thyroid Hormone Resistance
Selective Pituitary Resistance To Thyroid Hormone	Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion
Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion	Pituitary Resistance To Thyroid Hormone

Allan-Herndon-Dudley Syndrome

AHDS	Allan-Herndon Syndrome
Monocarboxylate Transporter 8 Deficiency	MCT8 DEFICIENCY
Mental Retardation, X-Linked, With Hypotonia	Triiodothyronine Resistance
T3 Resistance	Mental Retardation And Muscular Atrophy
Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency	Intellectual Disability And Muscular Atrophy
Monocarboxylate Transporter-8 Deficiency	T3 Resisitence
Triiodothyronine Resistence	X-Linked Intellectual Disability With Hypotonia
Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency	Monocarboxylate Transporter 8 Deficiency
X-Linked Intellectual Disability-Hypotonia Syndrome

Thrombasthenia

Graves Disease 1

Thyrotoxicosis	Graves Disease, Susceptibility To, 1
GRD1	Grd
Hyperthyroidism, Autoimmune	Hyperthyroidism
Hyperactive Thyroid Gland	Overactive Thyroid
Toxic Diffuse Goitre	Toxic Primary Thyroid Hyperplasia
Stokes Disease	Thyrotoxicosis With Goitre
Thyrotoxicosis Struma	Graves Disease
Goitre With Hyperthyroidism	Basedow Disease
Exophthalmic Goitre	Exophthalmic Struma
Flajani Disease	Graves Disease With Exophthalmos
Hyperthyroid Goitre	Hyperthyroidism Struma
Thyroid Exophthalmos	Malignant Exophthalmos
Parry Disease	Toxic Diffuse Goitre With Exophthalmos
Toxic Goitre	Toxic Goitre Nos
Thyrotoxicosis Due To Uninodular Goitre	Toxic Thyroid Nodule
Toxic Uninodular Goitre	Uninodular Toxic Struma
Uninodular Toxic Struma With Hyperthyroidism	Thyrotoxicosis Due To Single Thyroid Nodule
Toxic Uninodular Goitre With Hyperthyroidism	Hyperthyroidism With Thyroid Nodule
Thyrotoxicosis With Toxic Uninodular Goitre	Uninodular Goitre In Hyperthyroidism
Uninodular Goitre In Thyrotoxicosis	Toxic Multinodular Goitre
Multinodular Goitre With Thyrotoxicosis	Thyrotoxicosis Nodular Goitre
Nodular Goitre With Thyrotoxicosis	Adenomatous Goitre With Hyperthyroidism
Multinodular Goitre With Hyperthyroidism	Nodular Goitre With Hyperthyroidism
Nodular Struma With Hyperthyroidism	Plummer Disease
Thyrotoxicosis Adenomatous Goitre	Thyrotoxicosis Adenomatous Struma
Toxic Adenomatous Goitre	Toxic Adenomatous Struma
Toxic Nodular Goitre Nos	Toxic Struma Nodosa
Toxic Nodular Struma

Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14499	THRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	THRA	VGNC	VGNC:35845
Rattus norvegicus	THRA	RGD	RGD:3857
Mus musculus	THRA	MGD	MGI:98742
Macaca mulatta	THRA	VGNC	VGNC:78349
Canis familiaris	THRA	VGNC	VGNC:55828
Felis catus	THRA	VGNC	VGNC:66172
Others	THRA	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.