Ubash3b - ubiquitin associated and SH3 domain containing, B Gene

Mus musculus

Also known as p70; STS-1; TULA-2; 2810457I06Rik

Gene ID: 72828 | Gene type: protein coding

About Ubash3b

Summary

Enables phosphoprotein binding activity and protein tyrosine Phosphatase activity. Involved in regulation of osteoclast differentiation. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and platelet aggregation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; incisor; limb; nasal cavity epithelium; and retina. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2022]

Ubash3b Products(2)

mRNA	Protein	Name
NM_001357412.1	NP_001344341.1	ubiquitin-associated and SH3 domain-containing protein B isoform 2
NM_176860.6	NP_789830.1	ubiquitin-associated and SH3 domain-containing protein B isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoprotein binding	IDA IDA: Inferred from direct assay	27609517	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24256567	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	27609517	MGI
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	23149425	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within collagen-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	27609517	MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27609517	MGI
acts upstream of or within negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	23149425	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	23149425	MGI
acts upstream of or within negative regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	20585042	MGI
acts upstream of or within negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	27609517	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	20585042	MGI
acts upstream of or within negative regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	23149425	MGI
acts upstream of or within peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	27609517	MGI
acts upstream of or within peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	20585042	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	27609517	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	27609517	MGI
involved in regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	23149425	MGI
acts upstream of or within regulation of protein binding	IMP IMP: Inferred from mutant phenotype	27609517	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	20585042	MGI
acts upstream of signal transduction	IMP IMP: Inferred from mutant phenotype	23149425	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin-associated and SH3 domain-containing protein B

T-cell ubiquitin ligand 2	cbl-interacting protein p70
suppressor of T-cell receptor signaling 1	tyrosine-protein phosphatase STS1/TULA2

Ubash3b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ubash3b	Q8BGG7	ZAP70	Homo sapiens	P43403	Anti Bait CoIP	24256567
Cross	Ubash3b	Q8BGG7	ZAP70	Homo sapiens	P43403	Anti Tag CoIP	24256567
Cross	Ubash3b	Q8BGG7	ZAP70	Homo sapiens	P43403	Pull Down	24256567

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15332	UBASH3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ubash3b	NCBI	NCBI:84959

Name
Email *

	Sorry, but the email address you supplied was invalid.