UBASH3B - ubiquitin associated and SH3 domain containing B Gene

Homo sapiens

Also known as p70; STS1; STS-1; TULA2; TULA-2

Gene ID: 84959 | Gene type: protein coding

About UBASH3B

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:122,655,722-122,814,473 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and 1 paralogue. Broad expression in spleen (RPKM 7.0), placenta (RPKM 6.8) and 18 other tissues.

Summary

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

UBASH3B Products(2)

mRNA	Protein	Name
NM_001363365.2	NP_001350294.1	ubiquitin-associated and SH3 domain-containing protein B isoform 2
NM_032873.5	NP_116262.2	ubiquitin-associated and SH3 domain-containing protein B isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20585042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBASH3B Protein Structure

UBA

SH3_9

His_Phos_1

0
100
200
300
400
500
600
649 a.a.

Protein Preferred Names

Protein Names

ubiquitin-associated and SH3 domain-containing protein B

Cbl-interacting protein Sts-1

UBASH3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBASH3B	Q8TF42	SLC25A48	Homo sapiens	Q6ZT89	Y2H Prey Pooling	25416956
Intra	UBASH3B	Q8TF42	SLC25A48	Homo sapiens	Q6ZT89	Y2H Array	25416956
Intra	UBASH3B	Q8TF42	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	TNKS	Homo sapiens	O95271	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	TNKS	Homo sapiens	O95271	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	EFS	Homo sapiens	O43281-2	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	EFS	Homo sapiens	O43281-2	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	PRR35	Homo sapiens	P0CG20	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	PRR35	Homo sapiens	P0CG20	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	DLGAP2	Homo sapiens	Q9P1A6-3	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	CBLB	Homo sapiens	Q13191	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	CBLB	Homo sapiens	Q13191	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	UBASH3B	Q8TF42	DOC2A	Homo sapiens	Q14183	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	RCHY1	Homo sapiens	Q96PM5	Validated Y2H	25416956
Intra	UBASH3B	Q8TF42	RCHY1	Homo sapiens	Q96PM5	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	RCHY1	Homo sapiens	Q96PM5	Y2H Prey Pooling	25416956
Intra	UBASH3B	Q8TF42	RCHY1	Homo sapiens	Q96PM5	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	DOC2A	Homo sapiens	Q14183	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	RCHY1	Homo sapiens	Q96PM5	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	BBC3	Homo sapiens	Q96PG8	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	CCDC74B	Homo sapiens	Q96LY2-2	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	CCDC74B	Homo sapiens	Q96LY2-2	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	CCDC74B	Homo sapiens	Q96LY2-2	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	PTPN21	Homo sapiens	Q16825	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	PTPN21	Homo sapiens	Q16825	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	25416956
Intra	UBASH3B	Q8TF42	HOXB2	Homo sapiens	P14652	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	HOXB2	Homo sapiens	P14652	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	UBASH3B	Q8TF42	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	SPRY2	Homo sapiens	O43597	Y2H Array	25416956
Intra	UBASH3B	Q8TF42	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956
Intra	UBASH3B	Q8TF42	SYK	Homo sapiens	P43405	Phosphatase Assay	20585042
Intra	UBASH3B	Q8TF42	SYK	Homo sapiens	P43405	Pull Down	20585042
Intra	UBASH3B	Q8TF42	FAM168A	Homo sapiens	Q92567	Y2H Array	31515488
Intra	UBASH3B	Q8TF42	WASL	Homo sapiens	O00401	Y2H Array	32296183
Intra	UBASH3B	Q8TF42	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183
Intra	UBASH3B	Q8TF42	DMRT3	Homo sapiens	Q9NQL9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBASH3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74484	UBASH3B/STS1 Protein, Human (His)	Q8TF42 (Q382-E649)	≥95%

Related Diseases

Diseases

Alias

B-Cell Adult Acute Lymphocytic Leukemia

Adult B Acute Lymphoblastic Leukemia	Adult B Acute Lymphoblastic Leukaemia
Adult B-Cell Acute Lymphoblastic Leukaemia	Adult B-Cell Acute Lymphoblastic Leukemia
Adult B-Cell Lymphocytic Leukaemia	Adult B-Cell Lymphocytic Leukemia
Adult B-Lymphoblastic Leukaemia	Adult B-Lymphoblastic Leukemia
B-Cell Adult Acute Lymphocytic Leukaemia	B-Cell Adult Acute Lymphoblastic Leukemia

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15332	UBASH3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBASH3B	VGNC	VGNC:36575
Felis catus	UBASH3B	VGNC	VGNC:66756
Macaca mulatta	UBASH3B	VGNC	VGNC:79826
Mus musculus	UBASH3B	MGD	MGI:1920078
Rattus norvegicus	UBASH3B	RGD	RGD:1310357
Canis familiaris	UBASH3B	VGNC	VGNC:48048
Others	UBASH3B	NCBI

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