ZAP70 - zeta chain of T cell receptor associated protein kinase 70 Gene

Homo sapiens

Also known as SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70

Gene ID: 7535 | Gene type: protein coding

About ZAP70

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:97,713,576-97,756,364 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues, 32 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 11.2), spleen (RPKM 7.9) and 11 other tissues.

Summary

This gene encodes an Enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This Enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This Enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZAP70 Products(3)

mRNA	Protein	Name
NM_001079.4	NP_001070.2	tyrosine-protein kinase ZAP-70 isoform 1
NM_001378594.1	NP_001365523.1	tyrosine-protein kinase ZAP-70 isoform 1
NM_207519.2	NP_997402.1	tyrosine-protein kinase ZAP-70 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12447358	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7509083	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	15292186	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9489702	GOA
involved in immune response	IDA IDA: Inferred from direct assay	1423621	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	22732588	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	23620790	GOA
acts upstream of or within positive regulation of T cell differentiation	IDA IDA: Inferred from direct assay	7630421	GOA
acts upstream of or within positive thymic T cell selection	IDA IDA: Inferred from direct assay	7630421	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12447358	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
colocalizes with membrane raft	IDA IDA: Inferred from direct assay	12150984	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12150984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZAP70 Protein Structure

SH2

Pkinase_Tyr

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase ZAP-70

70 kDa zeta-associated protein

ZAP70 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZAP70	P43403	MET	Homo sapiens	P08581	FPS	24728074
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Peptide Array	15832366
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	SPR	9185620
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	ITC	10752619
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Pull Down	8648092
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	SPR	8648092
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Anti Bait CoIP	21957439
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Enzymatic Study	8901551
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Pull Down	7528772
Intra	ZAP70	P43403	CD3E	Homo sapiens	P07766	Pull Down	11855827
Intra	ZAP70	P43403	CD3E	Homo sapiens	P07766	SPR	7761456
Intra	ZAP70	P43403	LCK	Homo sapiens	P06239	Far-WB	10556826
Intra	ZAP70	P43403	LCK	Homo sapiens	P06239	Protein Kinase Assay	16461343
Intra	ZAP70	P43403	KIT	Homo sapiens	P10721	FPS	24728074
Intra	ZAP70	P43403	EGFR	Homo sapiens	P00533	Protein Array	16273093
Cross	ZAP70	P43403	Ubash3b	Mus musculus	Q8BGG7	Pull Down	24256567
Cross	ZAP70	P43403	Ubash3b	Mus musculus	Q8BGG7	Anti Tag CoIP	24256567

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 48

Combined Immunodeficiency Due To Zap70 Deficiency	IMD48
Selective T-Cell Defect	Stcd
Zeta-Associated-Protein 70 Deficiency	Severe Combined Immunodeficiency, Atypical
Immunodeficiency, Type 48	Zap70 Deficiency

Autoimmune Disease, Multisystem, Infantile-Onset, 2

ADMIO2

Autoimmune Disease, Multisystem, Infantile-Onset, Type 2

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Zap70-Related Severe Combined Immunodeficiency

Selective T-Cell Defect	Zap70-Related Scid
Zeta-Associated Protein 70 Deficiency	Zap70 Deficiency

Severe Combined Immunodeficiency, Atypical

Combined T And B Cell Immunodeficiency

Prolymphocytic Leukemia

Pll	Prolymphocytic Leukaemia
Leukemia Prolymphocytic	Leukemia, Prolymphocytic

Leukemia, Chronic Lymphocytic 2

Leukemia, Chronic Lymphocytic, Susceptibility To, 2	B-Cell Malignancy, Low-Grade
Clls2	Disrupted In B-Cell Malignancy
Dbm	Leukemia, Chronic Lymphocytic, B-Cell
Bcll	Lymphocytic Leukemia Chronic B-Cell
Chronic Lymphocytic Leukemia	Chronic Lymph Leukaemia
Chronic Lymphatic Leukaemia	Chronic Lymphocytic Leukaemia
Chronic Lymphoid Leukaemia	Lymphoplasmacytic Leukaemia

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

B-Cell Expansion With Nfkb And T-Cell Anergy

Benta Disease	BENTA
B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease	Persistent Polyclonal B-Cell Lymphocytosis
Lymphocytosis

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Purine Nucleoside Phosphorylase Deficiency

Purine-Nucleoside Phosphorylase Deficiency	Pnp Deficiency
Nucleoside Phosphorylase Deficiency	Immunodeficiency Due To Purine Nucleoside Phosphorylase Deficiency
Deficiency Of Inosine Phosphorylase	Pnpase Deficiency
PNPD

Chromosomal Triplication

Trisomy

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia	Macroglobulinemia Of Waldenstrom
Waldenström Macroglobulinemia	Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma	Waldenstrom'S Macroglobulinaemia
Waldenstrom'S Syndrome	Waldenstrom'S Macroglobulinemia
Wm	Waldenström'S Macroglobulinemia
Malignant Lymphoma - Lymphoplasmacytic

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll	B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Icdo:9823/3	Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Small Cell B-Cell Lymphoma

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Cd45 Deficiency

Cd40 Ligand Deficiency

X-Linked Hyper Igm Syndrome	Hyperimmunoglobulin M Syndrome
Higm1	Hyper-Igm Syndrome Type 1
X-Linked Hyper-Igm Syndrome	Xhigm
Higmx-1	X-Linked Hyper-Igm Immunodeficiency
Hyper-Igm Syndrome 1	Immunodeficiency With Hyper-Igm, Type 1
Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency	Hyper-Igm Syndrome Due To Cd40l Deficiency
Hyper-Igm Immunodeficiency Syndrome	Hyper-Igm Immunodeficiency Syndrome, Type 1

Chromosome 13q14 Deletion Syndrome

Chromosome 13q Deletion Syndrome	Deletion 13q14
Chromosome 13q Deletion	13q Deletion
13q Monosomy	Deletion 13q
Monosomy 13q	Monosomy 13q14
Del(13)(Q14)

Bare Lymphocyte Syndrome, Type Ii

Mhc Class Ii Deficiency	Bare Lymphocyte Syndrome
Major Histocompatibility Complex Class Ii Deficiency	Bare Lymphocyte Syndrome 2
Bare Lymphocyte Syndrome Type 2	Severe Combined Immunodeficiency, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group C	Bare Lymphocyte Syndrome, Type Ii, Complementation Group D
Bare Lymphocyte Syndrome Type Ii	Scid, Hla Class Ii-Negative
Bare Lymphocyte Syndrome, Type Ii, Complementation Group A	Bare Lymphocyte Syndrome, Type Ii, Complementation Group B
Scid Due To Absent Class Ii Hla Antigens	Hla Class 1 Deficiency
Scid, Hla Class 2-Negative	Bls Type Ii
Bare Lymphocyte Syndrome Type 2, Complementation Group A	Bare Lymphocyte Syndrome Type 2, Complementation Group E
Severe Combined Immunodeficiency	Bls, Type Ii
Bls	Bare Lymphocyte Syndrome, Type Ii, Complementation Group E
Blsii	Bls Type 1
Bls 2	Scid Due To Absence Of Class Ii Hla Antigens
Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens	Immunodeficiency By Defective Expression Of Mhc Class Ii
BLS2	Bare Lymphocyte Syndrome Type Ii Complementation Group A
Bare Lymphocyte Syndrome Type Ii Complementation Group B	Bare Lymphocyte Syndrome Type Ii Complementation Group C
Bare Lymphocyte Syndrome Type Ii Complementation Group D	Bare Lymphocyte Syndrome Type Ii Complementation Group E
Bls Ii	Hereditary Mhc Class Ii Deficiency
Hla Class Ii Deficient Combined Immunodeficiency	Mhc-Ii Deficiency
Scid Hla Class Ii-Negative	Severe Combined Immunodeficiency Hla Class Ii-Negative
Bl-2	Immunodeficiency By Defective Expression Of Hla Class 2
Hla Class 2-Negative Severe Combined Immunodeficiency

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

T Cell Deficiency

T Cell Immunodeficiency	T Lymphocyte Deficiency
T Lymphocyte Immunodeficiency	T-Lymphocyte Deficiency

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation

Severe Combined Immunodeficiency, Athabascan Type	Severe Combined Immunodeficiency Due To Dclre1c Deficiency
Rs-Scid	Scid, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, With Sensitivity To Ionizing Radiation
Scid Due To Artemis Deficiency	Scid Due To Dclre1c Deficiency
Scid, Athabascan Type	Scid, Athabaskan Type
Severe Combined Immunodeficiency Due To Artemis Deficiency	Severe Combined Immunodeficiency, Athabaskan Type
SCIDA	Severe Combined Immunodeficiency, Athabascan-Type
Artemis Deficiency	Severe Combined Immunodeficiency Athabaskan Type
Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive With Sensitivity To Ionizing Radiation	RSSCID
Athabascan Scid	Immunodeficiency, Severe Combined, Athabascan Type
Severe Combined Immunodeficiency, Athabaskan-Type

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Anemia, Autoimmune Hemolytic

Autoimmune Hemolytic Anemia	Idiopathic Autoimmune Hemolytic Anemia
Immuno-Hemolytic Anemia	Anemia, Hemolytic, Autoimmune
Autoimmune Haemolytic Anaemia	Autoimmune Hemolytic Anaemia
Acquired Autoimmune Hemolytic Anemia	Anemia Hemolytic Autoimmune
Familial Auto-Immune Hemolytic Anemia	Aha
Aiha

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency	Mhc Class I Deficiency
Bls, Type I	Bare Lymphocyte Syndrome Type I
Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency	Blsi
Mhc Class 1 Deficiency	Major Histocompatibility Complex Class 1 Deficiency
Bare Lymphocyte Syndrome 1	BLS1
Bls I	Bls Type I
Bl-1	Bare Lymphocyte Syndrome Type 1
Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1	Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens
Bls - [Bare Lymphocyte Syndrome] Nos

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Hematologic Cancer

Hematologic Neoplasm	Hematologic Neoplasms
Hematologic Malignancies	Blood Cancer
Hematologic Malignancy	Hematological Tumors
Hematopoietic And Lymphoid System Tumor	Hematopoietic Cancer
Hematopoietic Neoplasm	Hematopoietic Tumors
Malignant Hematopoietic Neoplasm	Liquid Tumor
Hematopoietic Neoplasms

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15322	PRT062607	Inhibitor	97.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136179	ZAP-180013	Inhibitor	99.79%	Unkown
HY-155978A	RDN2150 TFA		99.62%	Unkown
HY-155978	RDN2150		/	Unkown
HY-112319	MK-8457	Inhibitor	/	Unkown
HY-RS15951	ZAP70 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZAP70	VGNC	VGNC:37050
Mus musculus	ZAP70	MGD	MGI:99613
Rattus norvegicus	ZAP70	RGD	RGD:3983
Canis familiaris	ZAP70	VGNC	VGNC:54555
Macaca mulatta	ZAP70	VGNC	VGNC:78822
Felis catus	ZAP70	VGNC	VGNC:67158
Others	ZAP70	NCBI