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  2. UBE2B - ubiquitin conjugating enzyme E2 B Gene

UBE2B - ubiquitin conjugating enzyme E2 B Gene

Homo sapiens

Also known as HR6B; UBC2; HHR6B; RAD6B; E2-17kDa

Gene ID: 7320 | Gene type: protein coding

About UBE2B

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,371,569-134,392,108 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues and 24 paralogues. Ubiquitous expression in adrenal (RPKM 31.0), heart (RPKM 26.8) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this Enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

UBE2B Products(2)

mRNA Protein Name
NM_003337.4 NP_003328.1 ubiquitin-conjugating enzyme E2 B
NM_003337.4 NP_003328.1 ubiquitin-conjugating enzyme E2 B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12776193 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
38182926 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
10908344 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
10373550 GOA
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
18339854 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
14981545 GOA
involved in DNA repair IGI
IGI: Inferred from genetic interaction
1717990 GOA
involved in postreplication repair IDA
IDA: Inferred from direct assay
14981545 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
10373550 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
19123975 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
18339854 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
10373550 GOA
involved in response to UV IGI
IGI: Inferred from genetic interaction
1717990 GOA
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
14981545 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
10373550 GOA
Cellular Component GO Annotation Evidence Reference Source
part of HULC complex IDA
IDA: Inferred from direct assay
19410543 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18339854 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18339854 GOA
located in replication fork IDA
IDA: Inferred from direct assay
18363965 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2B Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 143)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 B

E2 protein

Recombinant UBE2B Proteins

Cat. No. Product Name Accession Purity
HY-P71398 UBE2B Protein, Human (HEK293, His) P63146 (M1-S152) ≥95%

Related Diseases

Diseases Alias
Halothane Hepatitis

Hepatitis Halothane

Johanson-Blizzard Syndrome

JBS

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness

Johanson Blizzard Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2B VGNC VGNC:78692
Canis familiaris UBE2B VGNC VGNC:56072
Bos taurus UBE2B VGNC VGNC:36577
Rattus norvegicus UBE2B RGD RGD:708345
Mus musculus UBE2B MGD MGI:102944
Felis catus UBE2B VGNC VGNC:102356
Others UBE2B NCBI