2. Gene
  3. USP4 - ubiquitin specific peptidase 4 Gene

USP4 - ubiquitin specific peptidase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UNP; Unph

Gene ID: 7375 | Gene type: protein coding

About USP4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,277,144-49,340,053 (from NCBI)

This gene has 14 transcripts (splice variants), 140 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 15.1), bone marrow (RPKM 14.6) and 25 other tissues.

Summary

The protein encoded by this gene is a Protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP4 Products(3)

mRNA Protein Name
NM_001251877.2 NP_001238806.1 ubiquitin carboxyl-terminal hydrolase 4 isoform c
NM_003363.4 NP_003354.2 ubiquitin carboxyl-terminal hydrolase 4 isoform a
NM_199443.3 NP_955475.1 ubiquitin carboxyl-terminal hydrolase 4 isoform b

USP4 Protein Structure

DUSP

DUSP: DUSP domain (31 - 122)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (140 - 226)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (301 - 920)

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  • 963 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 4

deubiquitinating enzyme 4

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I

TRPS1

Trichorhinophalangeal Syndrome Type I

Trps I

Trichorhinophalangeal Syndrome Type 1

Type I Trichorhinophalangeal Syndrome

Giedion Syndrome

Trp Syndrome

Tricho-Rhino-Phalangeal Syndrome 1

Trichorhinophalangeal Syndrome, Type Iii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13814 PR-619 99.38% Unkown
HY-103435 Vialinin A Inhibitor 99.89% Unkown
HY-RS15551 USP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP4 VGNC VGNC:66886
Bos taurus USP4 VGNC VGNC:36729
Macaca mulatta USP4 VGNC VGNC:78416
Rattus norvegicus USP4 RGD RGD:1587387
Mus musculus USP4 MGD MGI:98905
Canis familiaris USP4 VGNC VGNC:48195
Others USP4 NCBI