USP4 - ubiquitin specific peptidase 4 Gene

Homo sapiens

Also known as UNP; Unph

Gene ID: 7375 | Gene type: protein coding

About USP4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,277,144-49,340,053 (from NCBI)

This gene has 14 transcripts (splice variants), 140 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 15.1), bone marrow (RPKM 14.6) and 25 other tissues.

Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP4 Products(3)

mRNA	Protein	Name
NM_001251877.2	NP_001238806.1	ubiquitin carboxyl-terminal hydrolase 4 isoform c
NM_003363.4	NP_003354.2	ubiquitin carboxyl-terminal hydrolase 4 isoform a
NM_199443.3	NP_955475.1	ubiquitin carboxyl-terminal hydrolase 4 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenosine receptor binding	IPI IPI: Inferred from physical interaction	16339847	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	16316627	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22001210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11461834	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16472766	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	30514904	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	16316627	GOA
involved in protein deubiquitination	IMP IMP: Inferred from mutant phenotype	20595234	GOA
involved in protein localization to cell surface	IDA IDA: Inferred from direct assay	16339847	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	16472766	GOA
involved in spliceosomal tri-snRNP complex assembly	IMP IMP: Inferred from mutant phenotype	20595234	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16316627	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16339847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP4 Protein Structure

DUSP

Ubiquitin_3

UCH

0
200
400
600
800
963 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 4

deubiquitinating enzyme 4

USP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP4	Q13107	ADORA2A	Homo sapiens	P29274	Anti Tag CoIP	16339847
Intra	USP4	Q13107	RIPK1	Homo sapiens	Q13546	Anti Bait CoIP	23313255
Intra	USP4	Q13107	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	23313255
Intra	USP4	Q13107	HUWE1	Homo sapiens	Q7Z6Z7	Anti Bait CoIP	21522127
Intra	USP4	Q13107	MEPCE	Homo sapiens	Q7L2J0	Anti Tag CoIP	33961781
Intra	USP4	Q13107	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	19615732
Intra	USP4	Q13107	USP4	Homo sapiens	Q13107	GMS	22001210
Intra	USP4	Q13107	EDC3	Homo sapiens	Q96F86	Anti Tag CoIP	33961781
Intra	USP4	Q13107	PRPF3	Homo sapiens	O43395	Anti Tag CoIP	19615732
Intra	USP4	Q13107	TUT1	Homo sapiens	Q9H6E5	Anti Tag CoIP	19615732
Intra	USP4	Q13107	PRPF4	Homo sapiens	O43172	Anti Tag CoIP	19615732
Intra	USP4	Q13107	USP4	Homo sapiens	Q13107	NMR	22001210
Intra	USP4	Q13107	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	33961781
Intra	USP4	Q13107	MEPCE	Homo sapiens	Q7L2J0	Anti Tag CoIP	19615732
Intra	USP4	Q13107	PRPF3	Homo sapiens	O43395	Anti Tag CoIP	33961781
Intra	USP4	Q13107	TUT1	Homo sapiens	Q9H6E5	Anti Tag CoIP	33961781
Intra	USP4	Q13107	PRPF4	Homo sapiens	O43172	Anti Tag CoIP	33961781
Intra	USP4	Q13107	USP11	Homo sapiens	P51784	Anti Tag CoIP	33961781
Intra	USP4	Q13107	DCP1B	Homo sapiens	Q8IZD4	Anti Tag CoIP	19615732

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I	TRPS1
Trichorhinophalangeal Syndrome Type I	Trps I
Trichorhinophalangeal Syndrome Type 1	Type I Trichorhinophalangeal Syndrome
Giedion Syndrome	Trp Syndrome
Tricho-Rhino-Phalangeal Syndrome 1	Trichorhinophalangeal Syndrome, Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13814	PR-619		99.38%	Unkown
HY-103435	Vialinin A	Inhibitor	99.89%	Unkown
HY-RS15551	USP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP4	VGNC	VGNC:66886
Bos taurus	USP4	VGNC	VGNC:36729
Macaca mulatta	USP4	VGNC	VGNC:78416
Rattus norvegicus	USP4	RGD	RGD:1587387
Mus musculus	USP4	MGD	MGI:98905
Canis familiaris	USP4	VGNC	VGNC:48195
Others	USP4	NCBI

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