2. Gene
  3. PRPF3 - pre-mRNA processing factor 3 Gene

PRPF3 - pre-mRNA processing factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRP3; RP18; HPRP3; Prp3p; HPRP3P; SNRNP90

Gene ID: 9129 | Gene type: protein coding

About PRPF3

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,321,468-150,353,233 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 15.4), endometrium (RPKM 11.5) and 25 other tissues.

Summary

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]

PRPF3 Products(2)

mRNA Protein Name
NM_001350529.1 NP_001337458.1 U4/U6 small nuclear ribonucleoprotein Prp3 isoform 2
NM_004698.4 NP_004689.1 U4/U6 small nuclear ribonucleoprotein Prp3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15314151 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
involved in spliceosomal tri-snRNP complex assembly IDA
IDA: Inferred from direct assay
20595234 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Cajal body IDA
IDA: Inferred from direct assay
15257298 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
26912367 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20595234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF3 Protein Structure

PWI

PWI: PWI domain (8 - 78)

PRP3

PRP3: pre-mRNA processing factor 3 (PRP3) (308 - 522)

DUF1115

DUF1115: Protein of unknown function (DUF1115) (543 - 674)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

U4/U6 small nuclear ribonucleoprotein Prp3

PRP3 pre-mRNA processing factor 3 homolog

PRPF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRPF3 O43395 MID2 Homo sapiens Q9UJV3-2
Y2H Bait-Prey Pool
25910212
Intra
PRPF3 O43395 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25910212
Intra
PRPF3 O43395 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25910212
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25910212
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Y2H Bait-Prey Pool
25910212
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Y2H Array
25910212
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Y2H Array
32296183
Intra
PRPF3 O43395 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
PRPF3 O43395 MFAP1 Homo sapiens P55081
Y2H
22365833
Intra
PRPF3 O43395 MFAP1 Homo sapiens P55081
Anti Tag CoIP
22365833
Intra
PRPF3 O43395 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
Intra
PRPF3 O43395 OSBPL3 Homo sapiens Q9H4L5
Validated Y2H
32296183
Intra
PRPF3 O43395 SMNDC1 Homo sapiens O75940
Y2H
22365833
Intra
PRPF3 O43395 U2AF2 Homo sapiens P26368-2
Validated Y2H
32296183
Intra
PRPF3 O43395 U2AF2 Homo sapiens P26368-2
Y2H Array
32296183
Intra
PRPF3 O43395 U2AF2 Homo sapiens P26368-2
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
25910212
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9-2
Y2H Bait-Prey Pool
25910212
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
25910212
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra
PRPF3 O43395 PHC2 Homo sapiens Q8IXK0-5
Validated Y2H
25910212
Intra
PRPF3 O43395 PHC2 Homo sapiens Q8IXK0-5
Y2H Array
25910212
Intra
PRPF3 O43395 PHC2 Homo sapiens Q8IXK0-5
Y2H Bait-Prey Pool
25910212
Intra
PRPF3 O43395 PIP4K2B Homo sapiens P78356-2
Y2H Array
32296183
Intra
PRPF3 O43395 PIP4K2B Homo sapiens P78356-2
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 PIP4K2B Homo sapiens P78356-2
Validated Y2H
32296183
Intra
PRPF3 O43395 CCDC125 Homo sapiens Q86Z20
Validated Y2H
32296183
Intra
PRPF3 O43395 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra
PRPF3 O43395 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra
PRPF3 O43395 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 RNF151 Homo sapiens Q2KHN1
Y2H Array
32296183
Intra
PRPF3 O43395 RNF151 Homo sapiens Q2KHN1
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 RNF151 Homo sapiens Q2KHN1
Validated Y2H
32296183
Intra
PRPF3 O43395 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
PRPF3 O43395 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
PRPF3 O43395 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
32296183
Intra
PRPF3 O43395 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
32296183
Intra
PRPF3 O43395 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra
PRPF3 O43395 PSMD3 Homo sapiens O43242
Validated Y2H
25910212
Intra
PRPF3 O43395 PSMD3 Homo sapiens O43242
Y2H Bait-Prey Pool
25910212
Intra
PRPF3 O43395 PSMD3 Homo sapiens O43242
Y2H Array
25910212
Intra
PRPF3 O43395 TXLNA Homo sapiens P40222
Validated Y2H
32296183
Intra
PRPF3 O43395 TXLNA Homo sapiens P40222
Y2H Array
32296183
Intra
PRPF3 O43395 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
PRPF3 O43395 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
PRPF3 O43395 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 NKAPD1 Homo sapiens Q6ZUT1
Y2H Array
32296183
Intra
PRPF3 O43395 NKAPD1 Homo sapiens Q6ZUT1
Validated Y2H
32296183
Intra
PRPF3 O43395 NKAPD1 Homo sapiens Q6ZUT1
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 RABEP1 Homo sapiens Q15276
Validated Y2H
32296183
Intra
PRPF3 O43395 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
PRPF3 O43395 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 GPRASP2 Homo sapiens Q96D09
Y2H Array
25910212
Intra
PRPF3 O43395 GPRASP2 Homo sapiens Q96D09
Y2H Bait-Prey Pool
25910212
Intra
PRPF3 O43395 GPRASP2 Homo sapiens Q96D09
Validated Y2H
25910212
Intra
PRPF3 O43395 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
PRPF3 O43395 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
PRPF3 O43395 PRPF6 Homo sapiens O94906
Pull Down
16723661
Intra
PRPF3 O43395 PRPF6 Homo sapiens O94906
Anti Tag CoIP
28514442
Intra
PRPF3 O43395 PRPF6 Homo sapiens O94906
Anti Tag CoIP
33961781
Intra
PRPF3 O43395 SART1 Homo sapiens O43290
Y2H
16723661
Intra
PRPF3 O43395 SART1 Homo sapiens O43290
Anti Tag CoIP
33961781
Intra
PRPF3 O43395 SART1 Homo sapiens O43290
Anti Tag CoIP
28514442
Intra
PRPF3 O43395 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
PRPF3 O43395 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PRPF3 O43395 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra
PRPF3 O43395 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
PRPF3 O43395 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 NKAP Homo sapiens Q8N5F7
Anti Tag CoIP
22365833
Intra
PRPF3 O43395 TSPYL Homo sapiens Q6FI91
Y2H Array
32296183
Intra
PRPF3 O43395 TSPYL Homo sapiens Q6FI91
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 TSPYL Homo sapiens Q6FI91
Validated Y2H
32296183
Intra
PRPF3 O43395 SHKBP1 Homo sapiens Q8TBC3
Validated Y2H
32296183
Intra
PRPF3 O43395 SHKBP1 Homo sapiens Q8TBC3
Y2H Array
32296183
Intra
PRPF3 O43395 SHKBP1 Homo sapiens Q8TBC3
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 TRIM39 Homo sapiens Q9HCM9
Y2H Prey Pooling
25416956
Intra
PRPF3 O43395 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
PRPF3 O43395 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
PRPF3 O43395 DVL3 Homo sapiens Q92997
Pull Down
16189514
Intra
PRPF3 O43395 U2AF2 Homo sapiens P26368
Y2H
22365833
Intra
PRPF3 O43395 SART3 Homo sapiens Q15020
Anti Tag CoIP
33961781
Intra
PRPF3 O43395 SART3 Homo sapiens Q15020
Anti Tag CoIP
28514442
Intra
PRPF3 O43395 PRPF4 Homo sapiens O43172
Anti Tag CoIP
33961781
Intra
PRPF3 O43395 SF3B2 Homo sapiens Q13435
Anti Tag CoIP
22365833
Intra
PRPF3 O43395 SF3B2 Homo sapiens Q13435
Y2H
22365833
Intra
PRPF3 O43395 SLU7 Homo sapiens O95391
Anti Tag CoIP
22365833
Intra
PRPF3 O43395 SLU7 Homo sapiens O95391
Y2H
22365833
Intra
PRPF3 O43395 NACC1 Homo sapiens Q96RE7
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 NACC1 Homo sapiens Q96RE7
Validated Y2H
32296183
Intra
PRPF3 O43395 NACC1 Homo sapiens Q96RE7
Y2H Array
32296183
Intra
PRPF3 O43395 ZFPM2 Homo sapiens Q8WW38
Y2H Prey Pooling
32296183
Intra
PRPF3 O43395 ZFPM2 Homo sapiens Q8WW38
Validated Y2H
32296183
Intra
PRPF3 O43395 ZFPM2 Homo sapiens Q8WW38
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 18

RP18

Retinitis Pigmentosa-18

Retinitis Pigmentosa, Type 18
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis
Midline Cystocele
Microphthalmia, Syndromic 5

MCOPS5

Syndromic Microphthalmia Type 5

Retinal Dystrophy, Early-Onset, With Or Without Pituitary Dysfunction

Syndromic Microphthalmia 5

Syndromic Microphthalmia/Anophthalmia Due To Otx2 Mutation

Microphthalmia Syndromic 5

Otx2-Related Eye Disorders

Microphthalmia, Syndromic, 5

RDEOP

Microphthalmia, Syndromic, Type 5
Retinitis Pigmentosa 9

RP9

Retinitis Pigmentosa-9

Retinitis Pigmentosa, Type 9
Pseudoretinitis Pigmentosa

Secondary Pigmentary Retinal Degeneration

Secondary Pigmentary Degeneration Of Retina
Retinitis Pigmentosa 13

RP13

Retinitis Pigmentosa-13

Retinitis Pigmentosa, Type 13
Retinitis Pigmentosa 33

RP33

Retinitis Pigmentosa, Type 33
Retinitis Pigmentosa 63

RP63
Retinitis Pigmentosa 31

RP31

Retinitis Pigmentosa-31

Retinitis Pigmentosa, Type 31
Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome

Brachymelic Primordial Dwarfism

Cephaloskeletal Dysplasia

Low-Birth-Weight Dwarfism With Skeletal Dysplasia

Microcephalic Osteodysplastic Primordial Dwarfism Type I

Osteodysplastic Primordial Dwarfism Type I

Primordial Microcephalic Dwarfism, Crachami Type

Osteodysplastic Primordial Dwarfism, Type 1

MOPD1

Mopd I

Mopd

Osteodysplastic Primordial Dwarfism, Type I

Tals

Microcephalic Osteodysplastic Primordial Dwarfism Type 1

Mopd 1

Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

Mopd Types I And Iii

Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

Primordial Microcephalic Dwarfism Crachami Type

Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Retinitis Pigmentosa 1

RP1

Retinitis Pigmentosa-1

Retinitis Pigmentosa, Type 1
Mandibulofacial Dysostosis, Guion-Almeida Type

Mandibulofacial Dysostosis With Microcephaly

Mandibulofacial Dysostosis-Microcephaly Syndrome

MFDGA

MFDM

Mfdm Syndrome

Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate

Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate

Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome

Dysostosis, Mandibulofacial, Guion-Almeida Type
Retinal Degeneration

Degeneration Of Retina
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Eye Degenerative Disease
Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11
Stargardt Disease

Stargardt Disease 1

Stargardt Macular Dystrophy

Stargardt Disease-1

Juvenile Onset Macular Degeneration

Stargardt Macular Degeneration

Juvenile Macular Degeneration

Macular Dystrophy With Flecks, Type 1

Stgd

Fundus Flavimaculatus

Stargardt 1

Stargardts Disease
Cone Dystrophy

Retinal Cone Dystrophy

Dystrophy, Cone

Cone Dystrophy 3
Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital
Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome

Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

Graefe-Usher Syndrome

Hallgren Syndrome

Usher'S Syndrome

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa-Hearing Loss Syndrome

Ush

Usher Syndromes
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11207 PRPF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRPF3 VGNC VGNC:64370
Rattus norvegicus PRPF3 RGD RGD:1310555
Bos taurus PRPF3 VGNC VGNC:33373
Macaca mulatta PRPF3 VGNC VGNC:76277
Canis familiaris PRPF3 VGNC VGNC:45020
Mus musculus PRPF3 MGD MGI:1918017