Irak3 - interleukin-1 receptor-associated kinase 3 Gene

Mus musculus

Also known as IRAK-M; 4833428C18Rik

Gene ID: 73914 | Gene type: protein coding

About Irak3

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macrophage tolerance induction; and response to molecule of Bacterial origin. Acts upstream of or within interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; and protein autophosphorylation. Located in cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Irak3 Products(2)

mRNA	Protein	Name
NM_001359184.1	NP_001346113.1	interleukin-1 receptor-associated kinase 3 isoform 2
NM_028679.4	NP_082955.2	interleukin-1 receptor-associated kinase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12054681	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12054681	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	12054681	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12054681	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	12054681	MGI
acts upstream of or within interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	12054681	MGI
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17379480	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in negative regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	17379480	MGI
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12150927	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	12054681	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	29686383	MGI
involved in positive regulation of macrophage tolerance induction	IMP IMP: Inferred from mutant phenotype	12150927	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	12054681	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12054681	MGI
involved in regulation of protein-containing complex disassembly	IDA IDA: Inferred from direct assay	12054681	MGI
involved in response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	12150927	MGI
involved in response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	12150927	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17379480	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17379480	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-1 receptor-associated kinase 3

IL-1 receptor-associated kinase M

inactive IL-1 receptor-associated kinase 3

Irak3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Irak3	Q8K4B2	Irak4	Mus musculus	Q8R4K2	Anti Bait CoIP	23376919
Intra	Irak3	Q8K4B2	Traf6	Mus musculus	P70196	Anti Tag CoIP	23376919

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142662A	PROTAC IRAK3 degrade-1 formic		98.10%	Unkown
HY-142662	PROTAC IRAK3 degrade-1	Modulator	/	Unkown
HY-RS06897	IRAK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Irak3	NCBI	NCBI:11213

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