Tnks2 - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Gene

Mus musculus

Also known as ARTD6; Tank2; TNKS-2; 5430432P15Rik

Gene ID: 74493 | Gene type: protein coding

About Tnks2

Chromosome 19: 36,811,632-36,870,877 forward strand.GRCm39:CM001012.3

This gene has 9 transcripts (splice variants), 169 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in placenta adult (RPKM 24.7), CNS E11.5 (RPKM 2.9) and 28 other tissues.

Summary

Predicted to enable Enzyme binding activity; pentosyltransferase activity; and protein N-terminus binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tnks2 Products(1)

mRNA	Protein	Name
NM_001163635.1	NP_001157107.1	poly [ADP-ribose] polymerase tankyrase-2

Tnks2 Protein Structure

PTZ00322

ANK

PHA02876

ANK

PHA03095

ANK

SAM_tankyrase1,2

tankyrase_like

0
200
400
600
800
1000
1166 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase tankyrase-2

ADP-ribosyltransferase diphtheria toxin-like 6	TRF1-interacting ankyrin-related ADP-ribose polymerase 2
protein poly-ADP-ribosyltransferase tankyrase-2	tankyrase II
tankyrase-2	tankyrase-like protein
tankyrase-related protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-12438	G007-LK	Inhibitor	99.24%	Unkown
HY-13990	NVP-TNKS656		99.66%	Unkown
HY-16910	WIKI4	Inhibitor	99.93%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-U00422	K-756	Inhibitor	99.25%	Unkown
HY-145267	OM-153	Inhibitor	99.59%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-15811	XMD8-87	Inhibitor	98.15%	Unkown
HY-101243	XMD16-5	Inhibitor	98.59%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-121719	TIQ-A	Inhibitor	99.65%	Unkown
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-12601	TNKS 22	Inhibitor	/	Unkown
HY-145111	TNK2-IN-1	Inhibitor	/	Unkown
HY-145266	OM-1700	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1		/	Unkown
HY-153259	TNKS1/2-IN-2	Inhibitor	/	Unkown
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	Unkown
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	Unkown
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnks2	NCBI	NCBI:80351

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