XRCC5 - X-ray repair cross complementing 5 Gene

Homo sapiens

Also known as KU80; KUB2; Ku86; NFIV; KARP1; KARP-1

Gene ID: 7520 | Gene type: protein coding

About XRCC5

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:216,109,348-216,206,293 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 87.8), lymph node (RPKM 70.4) and 25 other tissues.

Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA Ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with Cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

XRCC5 Products(1)

mRNA	Protein	Name
NM_021141.4	NP_066964.1	X-ray repair cross-complementing protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to 5'-deoxyribose-5-phosphate lyase activity	IMP IMP: Inferred from mutant phenotype	20383123	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	9368068	GOA
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	9368068	GOA
contributes to DNA end binding	IDA IDA: Inferred from direct assay	9368068	GOA
enables DNA end binding	IDA IDA: Inferred from direct assay	19549901	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	14704337	GOA
enables U3 snoRNA binding	IDA IDA: Inferred from direct assay	32103174	GOA
contributes to double-stranded telomeric DNA binding	IDA IDA: Inferred from direct assay	10409678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8621488	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12377759	GOA
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	10535943	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18809223	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22266820	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	27248496	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	26359349	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	19581589	GOA
involved in double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	26359349	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	20383123	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	8621488	GOA
involved in negative regulation of t-circle formation	IMP IMP: Inferred from mutant phenotype	19581589	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	22504299	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	19188702	GOA
involved in regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25852083	GOA
involved in small-subunit processome assembly	IDA IDA: Inferred from direct assay	32103174	GOA
involved in telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	19188702	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA-dependent protein kinase complex	IPI IPI: Inferred from physical interaction	28840859	GOA
part of DNA-dependent protein kinase-DNA ligase 4 complex	IDA IDA: Inferred from direct assay	34352203	GOA
part of Ku70:Ku80 complex	IDA IDA: Inferred from direct assay	20383123	GOA
part of Ku70:Ku80 complex	IPI IPI: Inferred from physical interaction	11493912	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	10535943	GOA
part of nonhomologous end joining complex	IDA IDA: Inferred from direct assay	20383123	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	32103174	GOA
located in nucleus	IDA IDA: Inferred from direct assay	32103174	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	14704337	GOA
located in site of DNA damage	IMP IMP: Inferred from mutant phenotype	27248496	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	32103174	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRCC5 Protein Structure

Ku_N

Ku_C

Ku_PK_bind

0
200
400
600
732 a.a.

Protein Preferred Names

Protein Names

X-ray repair cross-complementing protein 5

86 kDa subunit of Ku antigen

XRCC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	XRCC5	P13010	HOXB7	Homo sapiens	P09629	Anti Bait CoIP	17308091
Intra	XRCC5	P13010	APLF	Homo sapiens	Q8IW19	Y2H	23178593
Intra	XRCC5	P13010	TPT1	Homo sapiens	P13693	Anti Bait CoIP	22451927
Intra	XRCC5	P13010	PAXX	Homo sapiens	Q9BUH6	Anti Bait CoIP	25574025
Intra	XRCC5	P13010	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	17308091
Intra	XRCC5	P13010	PRKDC	Homo sapiens	P78527	Anti Tag CoIP	26496610
Intra	XRCC5	P13010	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	20085707
Intra	XRCC5	P13010	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	25277244
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	10783163
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	TAP	24981860
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Crosslink	30021884
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	22451927
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	26496610
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	17308091
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	TAP	21679440
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Y2H Array	32296183
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Y2H Prey Pooling	32296183
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	21070772
Intra	XRCC5	P13010	XRCC6	Homo sapiens	P12956	Biochemical	17159921
Intra	XRCC5	P13010	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	XRCC5	P13010	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	XRCC5	P13010	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	XRCC5	P13010	COIL	Homo sapiens	P38432	Anti Bait CoIP	21070772

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XRCC5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73846	Ku70-Ku80 Heterodimer Protein, Human (sf9, His)	P13010 (M1-I732)&P12956 (M1-D609)	≥95%

XRCC5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80737	Ku80 Antibody (YA714)	WB, ICC/IF, IP, ChIP	Human, Monkey

Related Diseases

Diseases

Alias

Werner Syndrome

Werner'S Syndrome	WRN
Adult Progeria	Ws
Adult Premature Ageing Syndrome	Adult Premature Aging Syndrome
Werners Syndrome

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Viral Exanthem

Viral Rash Nos	Virus Exanthema
Nonspecific Exanthematous Viral Infection	Nonspecific Viral Exanthem
Nonspecific Viral Rash	Viral Enanthema Nos
Viral Disease Characterised By Exanthem	Viral Exanthemata
Viral Exanthem, Unspecified	Viral Exanthema Nos

Nijmegen Breakage Syndrome

Berlin Breakage Syndrome	NBS
Microcephaly, Normal Intelligence And Immunodeficiency	Ataxia-Telangiectasia Variant
Ataxia-Telangiectasia Variant V1	Seemanova Syndrome Ii
Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome	Seemanova Syndrome Type 2
At-V1	Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies
Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence	Immunodeficiency, Microcephaly, And Chromosomal Instability
Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome	Microcephaly Immunodeficiency Lymphoreticuloma
Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies	Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence
Seemanova Syndrome 2	Ataxia-Telangiectasia Variant 1
Seemanova Syndrome	At V1
Ataxia-Telangiectasia, Variant 1	Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome
V-At	Ataxia Telangiectasia Variant V1

Erythema Infectiosum

Fifth Disease	Slapped Cheek Syndrome
Parvovirus B19 Infection

Lig4 Syndrome

Dna Ligase Iv Deficiency	Ligase 4 Syndrome
LIG4S

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Hemangioma Of Subcutaneous Tissue

Angioma Of The Subcutaneous Tissue	Subcutaneous Haemangioma
Subcutaneous Hemangioma

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation

Severe Combined Immunodeficiency, Athabascan Type	Severe Combined Immunodeficiency Due To Dclre1c Deficiency
Rs-Scid	Scid, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, With Sensitivity To Ionizing Radiation
Scid Due To Artemis Deficiency	Scid Due To Dclre1c Deficiency
Scid, Athabascan Type	Scid, Athabaskan Type
Severe Combined Immunodeficiency Due To Artemis Deficiency	Severe Combined Immunodeficiency, Athabaskan Type
SCIDA	Severe Combined Immunodeficiency, Athabascan-Type
Artemis Deficiency	Severe Combined Immunodeficiency Athabaskan Type
Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive With Sensitivity To Ionizing Radiation	RSSCID
Athabascan Scid	Immunodeficiency, Severe Combined, Athabascan Type
Severe Combined Immunodeficiency, Athabaskan-Type

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Autosomal Recessive Cerebellar Ataxia

Arca

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15900	XRCC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	XRCC5	RGD	RGD:3976
Bos taurus	XRCC5	VGNC	VGNC:37006
Macaca mulatta	XRCC5	VGNC	VGNC:99422
Canis familiaris	XRCC5	VGNC	VGNC:48469
Felis catus	XRCC5	VGNC	VGNC:67120
Mus musculus	XRCC5	MGD	MGI:104517
Others	XRCC5	NCBI

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