ZNF3 - zinc finger protein 3 Gene

Homo sapiens

Also known as A8-51; HF.12; KOX25; PP838; Zfp113

Gene ID: 7551 | Gene type: protein coding

About ZNF3

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,063,837-100,082,577 (from NCBI)

This gene has 15 transcripts (splice variants), 178 orthologues and 174 paralogues. Ubiquitous expression in endometrium (RPKM 7.6), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF3 Products(22)

mRNA	Protein	Name
NM_001278284.2	NP_001265213.1	zinc finger protein 3 isoform 2
NM_001278287.2	NP_001265216.1	zinc finger protein 3 isoform 2
NM_001278290.2	NP_001265219.1	zinc finger protein 3 isoform 2
NM_001278291.2	NP_001265220.1	zinc finger protein 3 isoform 3
NM_001278292.2	NP_001265221.1	zinc finger protein 3 isoform 3
NM_001318135.2	NP_001305064.1	zinc finger protein 3 isoform 2
NM_001318136.2	NP_001305065.1	zinc finger protein 3 isoform 4
NM_001318137.2	NP_001305066.1	zinc finger protein 3 isoform 5
NM_001362775.2	NP_001349704.1	zinc finger protein 3 isoform 4
NM_001362776.2	NP_001349705.1	zinc finger protein 3 isoform 6
NM_001362777.2	NP_001349706.1	zinc finger protein 3 isoform 3
NM_001371210.1	NP_001358139.1	zinc finger protein 3 isoform 1
NM_001371211.1	NP_001358140.1	zinc finger protein 3 isoform 2
NM_001371212.1	NP_001358141.1	zinc finger protein 3 isoform 2
NM_001371213.1	NP_001358142.1	zinc finger protein 3 isoform 2
NM_001371214.1	NP_001358143.1	zinc finger protein 3 isoform 2
NM_001371215.1	NP_001358144.1	zinc finger protein 3 isoform 3
NM_001371216.1	NP_001358145.1	zinc finger protein 3 isoform 3
NM_001371217.1	NP_001358146.1	zinc finger protein 3 isoform 4
NM_001371218.1	NP_001358147.1	zinc finger protein 3 isoform 7
NM_017715.4	NP_060185.2	zinc finger protein 3 isoform 1
NM_032924.5	NP_116313.3	zinc finger protein 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18255255	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18255255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF3 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
446 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 3

C2-H2 type zinc finger protein

ZNF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF3	P17036	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	ZNF3	P17036	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	ZNF3	P17036	ZNF212	Homo sapiens	Q9UDV6	Y2H	18255255
Intra	ZNF3	P17036	ZNF212	Homo sapiens	Q9UDV6	Pull Down	18255255
Intra	ZNF3	P17036	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	ZNF3	P17036	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	32296183
Intra	ZNF3	P17036	MCC	Homo sapiens	P23508	Validated Y2H	32296183
Intra	ZNF3	P17036	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25416956
Intra	ZNF3	P17036	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ZNF3	P17036	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	ZNF3	P17036	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	ZNF3	P17036	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	ZNF3	P17036	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956
Intra	ZNF3	P17036	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	ZNF3	P17036	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	ZNF3	P17036	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	ZNF3	P17036	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	ZNF3	P17036	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	ZNF3	P17036	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	SF3B4	Homo sapiens	Q15427	Validated Y2H	32296183
Intra	ZNF3	P17036	SF3B4	Homo sapiens	Q15427	Y2H Array	32296183
Intra	ZNF3	P17036	YJU2B	Homo sapiens	P13994	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	YJU2B	Homo sapiens	P13994	Y2H Array	32296183
Intra	ZNF3	P17036	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	32296183
Intra	ZNF3	P17036	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	32296183
Intra	ZNF3	P17036	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16123	ZNF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZNF3	MGD	MGI:1929116
Rattus norvegicus	ZNF3	RGD	RGD:6489147
Macaca mulatta	ZNF3	VGNC	VGNC:81889
Bos taurus	ZNF3	VGNC	VGNC:37241

Name
Email *

	Sorry, but the email address you supplied was invalid.