ZBTB17 - zinc finger and BTB domain containing 17 Gene

Homo sapiens

Also known as MIZ-1; ZNF60; ZNF151; pHZ-67

Gene ID: 7709 | Gene type: protein coding

About ZBTB17

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:15,941,869-15,976,101 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 51 paralogues. Ubiquitous expression in bone marrow (RPKM 10.4), testis (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a zinc finger protein involved in the regulation of c-Myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

ZBTB17 Products(6)

mRNA	Protein	Name
NM_001242884.2	NP_001229813.1	zinc finger and BTB domain-containing protein 17 isoform 1
NM_001287603.2	NP_001274532.1	zinc finger and BTB domain-containing protein 17 isoform 3
NM_001287604.2	NP_001274533.1	zinc finger and BTB domain-containing protein 17 isoform 4
NM_001324137.2	NP_001311066.1	zinc finger and BTB domain-containing protein 17 isoform 4
NM_001324138.2	NP_001311067.1	zinc finger and BTB domain-containing protein 17 isoform 5
NM_003443.3	NP_003434.2	zinc finger and BTB domain-containing protein 17 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9312026	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9312026	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12244100	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19160485	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	9312026	GOA
enables core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19160485	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9308237	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	19160485	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of negative effect G1 to G0 transition	IDA IDA: Inferred from direct assay	19160485	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19160485	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9312026	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19160485	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-DNA complex	IMP IMP: Inferred from mutant phenotype	19160485	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19160485	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB17 Protein Structure

BTB

zf-H2C2_2

zf-C2H2_6

zf-H2C2_2

zf-C2H2_4

0
200
400
600
803 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 17

Myc-interacting Zn finger protein-1

Recombinant ZBTB17 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71437	ZBTB17 Protein, Human (His)	Q13105 (M1-A188)	≥95%

Related Diseases

Diseases

Alias

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15965	ZBTB17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZBTB17	VGNC	VGNC:48525
Mus musculus	ZBTB17	MGD	MGI:107410
Rattus norvegicus	ZBTB17	RGD	RGD:1307143
Bos taurus	ZBTB17	VGNC	VGNC:52849
Macaca mulatta	ZBTB17	VGNC	VGNC:78849
Felis catus	ZBTB17	VGNC	VGNC:67163
Others	ZBTB17	NCBI

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