RNF112 - ring finger protein 112 Gene

Homo sapiens

Also known as BFP; ZNF179

Gene ID: 7732 | Gene type: protein coding

About RNF112

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,411,232-19,417,276 (from NCBI)

This gene has 5 transcripts (splice variants), 129 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues.

Summary

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RNF112 Products(1)

mRNA	Protein	Name
NM_007148.5	NP_009079.2	RING finger protein 112

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron differentiation	IDA IDA: Inferred from direct assay	28684796	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	28684796	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF112 Protein Structure

zf-C3HC4

GBP

0
100
200
300
400
500
631 a.a.

Protein Preferred Names

Protein Names

RING finger protein 112

brain finger protein

RNF112 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF112	Q9ULX5	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	PARK7	Homo sapiens	Q99497	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PARK7	Homo sapiens	Q99497	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PARK7	Homo sapiens	Q99497	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	RNF112	Q9ULX5	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
Intra	RNF112	Q9ULX5	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	RNF112	Q9ULX5	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	RNF112	Q9ULX5	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	RNF112	Q9ULX5	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	RNF112	Q9ULX5	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	RNF112	Q9ULX5	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	RNF112	Q9ULX5	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	DBH	Homo sapiens	P09172	Y2H Array	32814053
Intra	RNF112	Q9ULX5	DBH	Homo sapiens	P09172	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Bilateral Generalized Polymicrogyria

Bilateral Generalised Polymicrogyria

Acute Diarrhea

Miller Fisher Syndrome

Cranial Variant Of Gbs	Fisher'S Syndrome
Miller-Fisher Variant Of Guillain-Barre Syndrome	Miller-Fisher Syndrome
Cranial Variant Of Guillain-Barré Syndrome	Cranial Variant Of Guillain-Barre Syndrome
Fisher Syndrome

Gummatous Syphilis

Bilateral Frontal Polymicrogyria

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Loeys-Dietz Syndrome 2

LDS2	Aat3
Marfan Syndrome Type 2	Aortic Aneurysm, Familial Thoracic 3
Marfan Syndrome Type Ii	Loeys-Dietz Syndrome Type 2
Mfs2	Marfan Syndrome, Type Ii, Formerly
Familial Throacic Aortic Aneurysm 3	Familial Aortic Aneurysm Thoracic Type 3
Taad2	Thoracic Aortic Aneurysms And Dissection 2
Aneurysm, Aortic, Thoracic, Familial, Type 3	Loeys-Dietz Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12037	RNF112 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF112	MGD	MGI:106611
Canis familiaris	RNF112	VGNC	VGNC:45622
Rattus norvegicus	RNF112	RGD	RGD:3986
Macaca mulatta	RNF112	VGNC	VGNC:76724
Bos taurus	RNF112	VGNC	VGNC:34011
Felis catus	RNF112	VGNC	VGNC:64664

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