2. Gene
  3. CACNG1 - calcium voltage-gated channel auxiliary subunit gamma 1 Gene

CACNG1 - calcium voltage-gated channel auxiliary subunit gamma 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CACNLG

Gene ID: 786 | Gene type: protein coding

About CACNG1

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:67,044,554-67,056,797 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues and 1 paralogue. Biased expression in esophagus (RPKM 1.9), prostate (RPKM 1.8) and 2 other tissues.

Summary

Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA Receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]

CACNG1 Products(1)

mRNA Protein Name
NM_000727.4 NP_000718.1 voltage-dependent calcium channel gamma-1 subunit
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACNG1 Protein Structure

Claudin_2

Claudin_2: PMP-22/EMP/MP20/Claudin tight junction (18 - 201)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-1 subunit

L-type calcium channel gamma polypeptide

CACNG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CACNG1 Q06432 VAPA Homo sapiens Q9P0L0
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
CACNG1 Q06432 VAPA Homo sapiens Q9P0L0
Y2H Array
32296183
Intra
CACNG1 Q06432 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CACNG1 Q06432 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CACNG1 Q06432 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
CACNG1 Q06432 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
CACNG1 Q06432 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
CACNG1 Q06432 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 ODF4 Homo sapiens Q2M2E3
Validated Y2H
32296183
Intra
CACNG1 Q06432 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
CACNG1 Q06432 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
CACNG1 Q06432 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
CACNG1 Q06432 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
CACNG1 Q06432 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
CACNG1 Q06432 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CACNG1 Q06432 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
CACNG1 Q06432 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CACNG1 Q06432 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
CACNG1 Q06432 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
CACNG1 Q06432 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
CACNG1 Q06432 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
CACNG1 Q06432 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
CACNG1 Q06432 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
CACNG1 Q06432 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 THAP4 Homo sapiens Q8WY91
Validated Y2H
32296183
Intra
CACNG1 Q06432 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra
CACNG1 Q06432 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
CACNG1 Q06432 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
CACNG1 Q06432 GAD2 Homo sapiens Q05329
Y2H Prey Pooling
32296183
Intra
CACNG1 Q06432 GAD2 Homo sapiens Q05329
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Hyperthermia

Anesthesia Related Hyperthermia

Malignant Hyperpyrexia Due To Anesthesia

Hyperpyrexia, Malignant

Hyperthermia, Malignant

Malignant Hyperpyrexia

Mhs

Malignant Fever
Autosomal Dominant Nonsyndromic Deafness 78

Dfna78
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Cenani-Lenz Syndactyly Syndrome

Syndactyly Type 7

Cenani Syndactylism

Cenani-Lenz Syndactyly

CLSS

Syndactyly Cenani Lenz Type

Cenani-Lenz Syndrome

Syndactyly, Type Vii

Cenani-Lenz Type Syndactyly

Cenani Syndactyly

Syndactyly Type Vii
Hypokalemic Periodic Paralysis, Type 1

Hypokalemic Periodic Paralysis

Hokpp

Hypopp

Westphall Disease

HOKPP1

Familial Hypokalemic Periodic Paralysis

Familial Periodic Paralysis

Westphal Disease

Hypokalemic Periodic Paralysis Type 1

Hypokalemic Familial Periodic Paralysis

Periodic Hypokalemic Paralysis

Periodic Paralysis I

Hypokpp

Primary Hypokalemic Periodic Paralysis

Periodic Paralysis Hypokalemic 1

Paralysis, Hypokalemic, Periodic

Paralysis, Hypokalemic, Periodic, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01809 CACNG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CACNG1 VGNC VGNC:26686
Rattus norvegicus CACNG1 RGD RGD:2249
Canis familiaris CACNG1 VGNC VGNC:38647
Mus musculus CACNG1 MGD MGI:1206582
Felis catus CACNG1 VGNC VGNC:98775
Macaca mulatta CACNG1 VGNC VGNC:82117