2. Gene
  3. SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KMT1B

Gene ID: 79723 | Gene type: protein coding

About SUV39H2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,878,866-14,904,315 (from NCBI)

This gene has 8 transcripts (splice variants), 145 orthologues and 19 paralogues. Broad expression in testis (RPKM 10.3), lymph node (RPKM 2.1) and 23 other tissues.

Summary

Enables S-adenosyl-L-methionine binding activity; Histone Methyltransferase activity (H3-K9 specific); and zinc ion binding activity. Involved in chromatin assembly or disassembly and chromatin remodeling. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SUV39H2 Products(5)

mRNA Protein Name
NM_001193424.2 NP_001180353.1 histone-lysine N-methyltransferase SUV39H2 isoform 1
NM_001193425.2 NP_001180354.1 histone-lysine N-methyltransferase SUV39H2 isoform 2
NM_001193426.2 NP_001180355.1 histone-lysine N-methyltransferase SUV39H2 isoform 3
NM_001193427.2 NP_001180356.1 histone-lysine N-methyltransferase SUV39H2 isoform 4
NM_024670.4 NP_078946.1 histone-lysine N-methyltransferase SUV39H2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
20084102 GOA
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
10949293 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
30111536 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
20084102 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to hypoxia IDA
IDA: Inferred from direct assay
21402781 GOA
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
10949293 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
10949293 GOA
involved in epigenetic programming in the zygotic pronuclei IDA
IDA: Inferred from direct assay
30111536 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21402781 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
10949293 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
30111536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUV39H2 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (47 - 94)

Pre-SET

Pre-SET: Pre-SET motif (147 - 242)

SET

SET: SET domain (262 - 373)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SUV39H2

H3-K9-HMTase 2

SUV39H2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SUV39H2 Q9H5I1 HEL25 Homo sapiens V9HWG0
Y2H Array
25416956
Intra
SUV39H2 Q9H5I1 PHF19 Homo sapiens Q5T6S3
Anti Tag CoIP
23455924
Intra
SUV39H2 Q9H5I1 PHF19 Homo sapiens Q5T6S3
Y2H
23455924
Intra
SUV39H2 Q9H5I1 PNMA1 Homo sapiens Q8ND90
MAPPIT
25416956
Intra
SUV39H2 Q9H5I1 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
SUV39H2 Q9H5I1 APPL2 Homo sapiens Q8NEU8
Y2H Array
31515488
Intra
SUV39H2 Q9H5I1 APPL2 Homo sapiens Q8NEU8
Validated Y2H
25416956
Intra
SUV39H2 Q9H5I1 APPL2 Homo sapiens Q8NEU8
Y2H Array
25416956
Intra
SUV39H2 Q9H5I1 KCTD17 Homo sapiens Q8N5Z5
Y2H
23455924
Intra
SUV39H2 Q9H5I1 KCTD17 Homo sapiens Q8N5Z5
Anti Tag CoIP
23455924
Intra
SUV39H2 Q9H5I1 KLHDC4 Homo sapiens Q8TBB5
Anti Tag CoIP
23455924
Intra
SUV39H2 Q9H5I1 KLHDC4 Homo sapiens Q8TBB5
Y2H
23455924
Intra
SUV39H2 Q9H5I1 MRFAP1 Homo sapiens Q9Y605
Y2H
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122181B OTS186935 hydrochloride Inhibitor 99.22% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-122182 OTS193320 98.64% Unkown
HY-122181 OTS186935 Inhibitor 98.55% Unkown
HY-148817 WDR5-0102 Inhibitor 97.02% Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-RS14052 SUV39H2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SUV39H2 VGNC VGNC:35492
Macaca mulatta SUV39H2 VGNC VGNC:103876
Rattus norvegicus SUV39H2 RGD RGD:1306969
Felis catus SUV39H2 VGNC VGNC:65858
Canis familiaris SUV39H2 VGNC VGNC:84435
Mus musculus SUV39H2 MGD MGI:1890396