PHF19 - PHD finger protein 19 Gene

Homo sapiens

Also known as PCL3; MTF2L1; TDRD19B

Gene ID: 26147 | Gene type: protein coding

About PHF19

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,855,651-120,904,128 (from NCBI)

This gene has 14 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 8.7), ovary (RPKM 6.6) and 24 other tissues.

Summary

Enables methylated histone binding activity. Involved in positive regulation of histone H3-K27 methylation. Colocalizes with ESC/E(Z) complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF19 Products(5)

mRNA	Protein	Name
NM_001009936.3	NP_001009936.1	PHD finger protein 19 isoform b
NM_001286840.1	NP_001273769.1	PHD finger protein 19 isoform c
NM_001286842.1	NP_001273771.1	PHD finger protein 19 isoform d
NM_001286843.2	NP_001273772.1	PHD finger protein 19 isoform e
NM_015651.3	NP_056466.1	PHD finger protein 19 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	23104054	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23104054	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	23104054	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	23104054	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF19 Protein Structure

PHD

Mtf2_C

0
100
200
300
400
500
580 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 19

polycomb like 3

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10419	PHF19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHF19	VGNC	VGNC:64140
Bos taurus	PHF19	VGNC	VGNC:32817
Mus musculus	PHF19	MGD	MGI:1921266
Macaca mulatta	PHF19	VGNC	VGNC:75857
Canis familiaris	PHF19	VGNC	VGNC:59040
Rattus norvegicus	PHF19	RGD	RGD:1310390

Name
Email *

	Sorry, but the email address you supplied was invalid.