2. Gene
  3. CPSF7 - cleavage and polyadenylation specific factor 7 Gene

CPSF7 - cleavage and polyadenylation specific factor 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CFIm59

Gene ID: 79869 | Gene type: protein coding

About CPSF7

This gene has 26 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 25.0), testis (RPKM 24.0) and 25 other tissues.

Summary

Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]

CPSF7 Products(3)

mRNA Protein Name
NM_001136040.4 NP_001129512.1 cleavage and polyadenylation specificity factor subunit 7 isoform 2
NM_001142565.3 NP_001136037.1 cleavage and polyadenylation specificity factor subunit 7 isoform 3
NM_024811.4 NP_079087.3 cleavage and polyadenylation specificity factor subunit 7 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: Inferred from direct assay
29276085 GOA
involved in mRNA 3'-end processing IDA
IDA: Inferred from direct assay
20695905 GOA
involved in mRNA alternative polyadenylation IMP
IMP: Inferred from mutant phenotype
20695905 GOA
involved in protein heterotetramerization IDA
IDA: Inferred from direct assay
23187700 GOA
involved in protein tetramerization IDA
IDA: Inferred from direct assay
20695905 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19864460 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
23187700 GOA
part of mRNA cleavage factor complex IDA
IDA: Inferred from direct assay
20695905 GOA
part of mRNA cleavage factor complex IPI
IPI: Inferred from physical interaction
20695905 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19864460 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF7 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (84 - 155)

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  • 471 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 7

CPSF 59 kDa subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03121 CPSF7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CPSF7 MGD MGI:1917826
Bos taurus CPSF7 VGNC VGNC:27675
Felis catus CPSF7 VGNC VGNC:61145
Macaca mulatta CPSF7 VGNC VGNC:71606
Rattus norvegicus CPSF7 RGD RGD:1305441
Canis familiaris CPSF7 VGNC VGNC:39578
Others CPSF7 NCBI