2. Gene
  3. U2AF2 - U2 small nuclear RNA auxiliary factor 2 Gene

U2AF2 - U2 small nuclear RNA auxiliary factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as U2AF65

Gene ID: 11338 | Gene type: protein coding

About U2AF2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,655,035-55,674,716 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 33.5), appendix (RPKM 33.2) and 25 other tissues.

Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

U2AF2 Products(2)

mRNA Protein Name
NM_001012478.2 NP_001012496.1 splicing factor U2AF 65 kDa subunit isoform b
NM_007279.3 NP_009210.1 splicing factor U2AF 65 kDa subunit isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
19574390 GOA
enables molecular function inhibitor activity EXP
EXP: Inferred from Experiment
32188783 GOA
enables pre-mRNA 3'-splice site binding IDA
IDA: Inferred from direct assay
2531895 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9237760 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
1824937 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
15009664 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
24389012 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
24389012 GOA
involved in positive regulation of RNA splicing IDA
IDA: Inferred from direct assay
21536736 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Prp19 complex IDA
IDA: Inferred from direct assay
21536736 GOA
part of U2-type prespliceosome IDA
IDA: Inferred from direct assay
2531895 GOA
part of U2AF complex IDA
IDA: Inferred from direct assay
1824937 GOA
part of U2AF complex IPI
IPI: Inferred from physical interaction
11551507 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
1824937 GOA
located in nucleus IDA
IDA: Inferred from direct assay
1824937 GOA
part of spliceosomal complex IDA
IDA: Inferred from direct assay
9731529 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
11551507 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

U2AF2 Protein Structure

(151 - 225)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (261 - 330)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (400 - 459)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

splicing factor U2AF 65 kDa subunit

U2 (RNU2) small nuclear RNA auxiliary factor 2

U2AF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
U2AF2 P26368 DACH1 Homo sapiens Q9UI36-2
Validated Y2H
25416956
Intra
U2AF2 P26368 DACH1 Homo sapiens Q9UI36-2
Y2H Array
25416956
Intra
U2AF2 P26368 PUF60 Homo sapiens Q9UHX1
Y2H Pooling
16189514
Intra
U2AF2 P26368 CHERP Homo sapiens Q8IWX8
Y2H
22365833
Intra
U2AF2 P26368 SUGP1 Homo sapiens Q8IWZ8
Anti Tag CoIP
22365833
Intra
U2AF2 P26368 SCAF11 Homo sapiens Q99590
Anti Tag CoIP
33961781
Intra
U2AF2 P26368 SCAF11 Homo sapiens Q99590
Y2H
21988832
Intra
U2AF2 P26368 SRSF1 Homo sapiens Q07955
Anti Tag CoIP
33961781
Intra
U2AF2 P26368 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra
U2AF2 P26368 SNRPA Homo sapiens P09012
Y2H
22365833
Intra
U2AF2 P26368 SNRPA Homo sapiens P09012
Y2H Prey Pooling
25416956
Intra
U2AF2 P26368 SNRPA Homo sapiens P09012
Y2H Array
25416956
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Y2H
21988832
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Y2H Prey Pooling
25416956
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Pull Down
21460037
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Anti Tag CoIP
35271311
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Anti Bait CoIP
21460037
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
X-Ray Diffraction
11551507
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Y2H Array
25416956
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Y2H
21516116
Intra
U2AF2 P26368 U2AF1 Homo sapiens Q01081
Anti Tag CoIP
33961781
Intra
U2AF2 P26368 SNW1 Homo sapiens Q13573
Pull Down
21460037
Intra
U2AF2 P26368 SNW1 Homo sapiens Q13573
Anti Bait CoIP
21460037
Intra
U2AF2 P26368 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
U2AF2 P26368 RBM10 Homo sapiens P98175
Anti Tag CoIP
35271311
Intra
U2AF2 P26368 RBM10 Homo sapiens P98175
Anti Tag CoIP
22365833
Intra
U2AF2 P26368 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
U2AF2 P26368 THAP1 Homo sapiens Q9NVV9
Y2H Pooling
16189514
Intra
U2AF2 P26368 PRPF3 Homo sapiens O43395
Anti Tag CoIP
22365833
Intra
U2AF2 P26368 PRPF3 Homo sapiens O43395
Anti Tag CoIP
35271311
Intra
U2AF2 P26368 SF1 Homo sapiens Q15637
Pull Down
26420826
Intra
U2AF2 P26368 SF1 Homo sapiens Q15637
Pull Down
12718882
Intra
U2AF2 P26368 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Intra
U2AF2 P26368 SF1 Homo sapiens Q15637
Anti Tag CoIP
35271311
Intra
U2AF2 P26368 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153736 NSC 194308 98.40% Unkown
HY-RS15314 U2AF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus U2AF2 RGD RGD:1310690
Felis catus U2AF2 VGNC VGNC:66741
Canis familiaris U2AF2 VGNC VGNC:48032
Bos taurus U2AF2 VGNC VGNC:36556
Mus musculus U2AF2 MGD MGI:98886
Others U2AF2 NCBI