U2AF2 - U2 small nuclear RNA auxiliary factor 2 Gene

Homo sapiens

Also known as U2AF65

Gene ID: 11338 | Gene type: protein coding

About U2AF2

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,655,035-55,674,716 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 33.5), appendix (RPKM 33.2) and 25 other tissues.

Summary

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

U2AF2 Products(2)

mRNA	Protein	Name
NM_001012478.2	NP_001012496.1	splicing factor U2AF 65 kDa subunit isoform b
NM_007279.3	NP_009210.1	splicing factor U2AF 65 kDa subunit isoform a

U2AF2 Protein Structure

RRM_1

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

splicing factor U2AF 65 kDa subunit

U2 (RNU2) small nuclear RNA auxiliary factor 2

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1	SCA1
Olivopontocerebellar Atrophy I	Opca1
Opca4	Menzel Type Opca
Schut-Haymaker Type Opca	Spinocerebellar Atrophy I
Opca I	Olivopontocerebellar Atrophy Iv
Opca Iv	Cerebelloparenchymal Disorder I
Cpd1	Olivopontocerebellar Atrophy 1
Cerebelloparenchymal Disorder 1	Olivopontocerebellar Atrophy 4
Spinocerebellar Atrophy 1	Type 1 Spinocerebellar Ataxia
Spinocerebellar Ataxia-1	Ataxia, Spinocerebellar, Type 1

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153736	NSC 194308		98.40%	Unkown
HY-RS15314	U2AF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	U2AF2	RGD	RGD:1310690
Felis catus	U2AF2	VGNC	VGNC:66741
Canis familiaris	U2AF2	VGNC	VGNC:48032
Bos taurus	U2AF2	VGNC	VGNC:36556
Mus musculus	U2AF2	MGD	MGI:98886
Others	U2AF2	NCBI

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