RIN3 - Ras and Rab interactor 3 Gene

Homo sapiens

Gene ID: 79890 | Gene type: protein coding

About RIN3

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,513,781-92,688,994 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 13.0), spleen (RPKM 13.0) and 24 other tissues.

Summary

Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RIN3 Products(2)

mRNA	Protein	Name
NM_001319987.2	NP_001306916.1	ras and Rab interactor 3 isoform 2
NM_024832.5	NP_079108.3	ras and Rab interactor 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	21586568	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	21586568	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of negative regulation of mast cell chemotaxis	IMP IMP: Inferred from mutant phenotype	23185384	GOA
acts upstream of or within negative regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	23185384	GOA
acts upstream of or within regulation of vesicle size	IDA IDA: Inferred from direct assay	32552912	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18486601	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	21586568	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21586568	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	18486601	GOA
located in vesicle	IDA IDA: Inferred from direct assay	32552912	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIN3 Protein Structure

VPS9

0
200
400
600
800
985 a.a.

Protein Preferred Names

Protein Names

ras and Rab interactor 3

RAB5 interacting protein 3

RIN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RIN3	Q8TB24	CD2AP	Homo sapiens	Q9Y5K6	Anti Tag CoIP	32552912
Intra	RIN3	Q8TB24	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	RIN3	Q8TB24	BIN1	Homo sapiens	O00499	Anti Tag CoIP	32552912
Intra	RIN3	Q8TB24	BIN1	Homo sapiens	O00499	Anti Tag CoIP	12972505
Intra	RIN3	Q8TB24	BIN1	Homo sapiens	O00499	Y2H	12972505
Intra	RIN3	Q8TB24	BIN1	Homo sapiens	O00499	Pull Down	12972505
Intra	RIN3	Q8TB24	PLCG1	Homo sapiens	P19174	Pull Down	17474147
Intra	RIN3	Q8TB24	PLCG1	Homo sapiens	P19174	Peptide Array	17474147
Intra	RIN3	Q8TB24	CRK	Homo sapiens	P46108	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Myostatin-Related Muscle Hypertrophy

Mslhp

Muscle Hypertrophy Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139990	CSF1R-IN-3	Inhibitor	98.26%	Unkown
HY-157398	EGFR T790M/L858R-IN-3	Inhibitor	/	Unkown
HY-161567	OX2R-IN-3	Antagonist	/	Unkown
HY-RS11984	RIN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RIN3	VGNC	VGNC:45588
Rattus norvegicus	RIN3	RGD	RGD:1305849
Macaca mulatta	RIN3	VGNC	VGNC:76771
Felis catus	RIN3	VGNC	VGNC:64635
Mus musculus	RIN3	MGD	MGI:2385708
Bos taurus	RIN3	VGNC	VGNC:53950
Others	RIN3	NCBI

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