2. Gene
  3. PDCD1LG2 - programmed cell death 1 ligand 2 Gene

PDCD1LG2 - programmed cell death 1 ligand 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2

Gene ID: 80380 | Gene type: protein coding

About PDCD1LG2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,510,531-5,571,282 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues, 12 paralogues and is associated with 52 phenotypes. Broad expression in spleen (RPKM 7.3), lymph node (RPKM 5.3) and 21 other tissues.

Summary

Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2022]

PDCD1LG2 Products(1)

mRNA Protein Name
NM_025239.4 NP_079515.2 programmed cell death 1 ligand 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20587542 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
12538684 GOA
involved in negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
12538684 GOA
involved in negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
12538684 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD1LG2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (31 - 106)

Ig_3

Ig_3: Immunoglobulin domain (126 - 196)

  • 0
  • 100
  • 200
  • 273 a.a.
Protein Preferred Names Protein Names

programmed cell death 1 ligand 2

B7 dendritic cell molecule

PDCD1LG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PDCD1LG2 Q9BQ51 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra PDCD1LG2 Q9BQ51 TAS2R10 Homo sapiens Q9NYW0
Validated Y2H
32296183
Intra PDCD1LG2 Q9BQ51 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra PDCD1LG2 Q9BQ51 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra PDCD1LG2 Q9BQ51 PDCD1 Homo sapiens Q15116
SPR
20587542
Intra PDCD1LG2 Q9BQ51 PDCD1 Homo sapiens Q15116
NMR
23417675
Intra PDCD1LG2 Q9BQ51 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra PDCD1LG2 Q9BQ51 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD1LG2 Proteins

Cat. No. Product Name Accession Purity
HY-P7399 PD-L2 Protein, Human (HEK293, Fc) Q9BQ51-1 (L20-P219) ≥95%
HY-P70734 PD-L2 Protein, Human (HEK293, mFc) Q9BQ51-1 (L20-P219) ≥95%
HY-P72407 PD-L2 Protein, Human (Biotinylated, HEK293, His-Avi) Q9BQ51-1 (L20-P219) ≥95%
HY-P72492 PD-L2 Protein, Human (HEK293, His) Q9BQ51-1 (L20-P219) ≥95%
HY-P77528 PD-L2 Protein, Human (Biotinylated, HEK293, His) Q9BQ51-1 (L20-P219) ≥95%
HY-P78505 PD-L2 Protein, Human (HEK293, His-Avi) Q9BQ51-1 (L20-T220) ≥95%

Related Diseases

Diseases Alias
Cysticercosis

Neurocysticercosis

Submacular Cysticercosis

Intestinal Taenia Solium Infection

Pork Tapeworm Infection

Tapeworm Infection: Intestinal Taenia Solum

Tapeworm Infection: Pork

Tenia Solium Infectious Disease

Taeniasis

Tenia Solium Infection

Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Autoimmune Cardiomyopathy
Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis
Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Gray Zone Lymphoma

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction

Adenocarcinoma Of Gastroesophageal Junction

Adenocarcinoma Of The Gastroesophageal Junction
Lung Non-Squamous Non-Small Cell Carcinoma

Non- Squamous Nsclc
Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21

Iddm21

T1D21

Insulin-Dependent Diabetes Mellitus 21
Selective Igg Deficiency Disease

Igg Deficiency

Immunoglobin G Subclass Deficiency

Selective Deficiency Of Igg

Selective Igg Immunodeficiency

Selective Immunoglobulin G Deficiency

Selective Immunoglobulin G Subclass Deficiency
Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma
Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications
Necrotizing Gastritis
Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor

Hematopoietic Neoplasm Of Central Nervous System

Central Nervous System Hematopoietic Neoplasm
Central Nervous System Lymphoma

Microglioma

Primary Cns Lymphoma

Cns Lymphoma

Primary Central Nervous System Lymphoma
Penis Carcinoma In Situ

Carcinoma In Situ Of Penis

Bowen'S Disease Of Penis

Grade Iii Squamous Intraepithelial Lesion Of Penis

Penile Intraepithelial Neoplasia Grade Iii

Queyrat'S Erythroplasia

Erythroplasia Of Queyrat

Pin - [Penile Intraepithelial Neoplasia]
Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified
Endocervical Carcinoma

Carcinoma Of Endocervix

Carcinoma Of The Endocervix
Refractory Plasma Cell Neoplasm
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Head And Neck Cancer

Head And Neck Neoplasm

Head And Neck Tumours

Head/Neck Neoplasm

Tumor Of Head And Neck

Head And Neck Neoplasms

Hnc

Cancer, Head/Neck
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10190 PDCD1LG2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PDCD1LG2 VGNC VGNC:56980
Rattus norvegicus PDCD1LG2 RGD RGD:1306403
Canis familiaris PDCD1LG2 VGNC VGNC:44336
Mus musculus PDCD1LG2 MGD MGI:1930125
Felis catus PDCD1LG2 VGNC VGNC:64078
Macaca mulatta PDCD1LG2 VGNC VGNC:75645
Macaca fascicularis PDCD1LG2 NCBI NCBI:102146227
Others PDCD1LG2 NCBI