PDCD1LG2 - programmed cell death 1 ligand 2 Gene

Homo sapiens

Also known as B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2

Gene ID: 80380 | Gene type: protein coding

About PDCD1LG2

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,510,531-5,571,282 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues, 12 paralogues and is associated with 52 phenotypes. Broad expression in spleen (RPKM 7.3), lymph node (RPKM 5.3) and 21 other tissues.

Summary

Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2022]

PDCD1LG2 Products(1)

mRNA	Protein	Name
NM_025239.4	NP_079515.2	programmed cell death 1 ligand 2 precursor

PDCD1LG2 Protein Structure

Ig_2

Ig_3

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

programmed cell death 1 ligand 2

B7 dendritic cell molecule

Recombinant PDCD1LG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7399	PD-L2 Protein, Human (HEK293, Fc)	Q9BQ51-1 (L20-P219)	≥95%
HY-P70734	PD-L2 Protein, Human (HEK293, mFc)	Q9BQ51-1 (L20-P219)	≥95%
HY-P72407	PD-L2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9BQ51-1 (L20-P219)	≥95%
HY-P72492	PD-L2 Protein, Human (HEK293, His)	Q9BQ51-1 (L20-P219)	≥95%
HY-P77528	PD-L2 Protein, Human (Biotinylated, HEK293, His)	Q9BQ51-1 (L20-P219)	≥95%
HY-P78505	PD-L2 Protein, Human (HEK293, His-Avi)	Q9BQ51-1 (L20-T220)	≥95%

Related Diseases

Diseases

Alias

Cysticercosis

Neurocysticercosis	Submacular Cysticercosis
Intestinal Taenia Solium Infection	Pork Tapeworm Infection
Tapeworm Infection: Intestinal Taenia Solum	Tapeworm Infection: Pork
Tenia Solium Infectious Disease	Taeniasis
Tenia Solium Infection	Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Autoimmune Cardiomyopathy

Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Gray Zone Lymphoma

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma

Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction	Adenocarcinoma Of Gastroesophageal Junction
Adenocarcinoma Of The Gastroesophageal Junction

Lung Non-Squamous Non-Small Cell Carcinoma

Non- Squamous Nsclc

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Selective Igg Deficiency Disease

Igg Deficiency	Immunoglobin G Subclass Deficiency
Selective Deficiency Of Igg	Selective Igg Immunodeficiency
Selective Immunoglobulin G Deficiency	Selective Immunoglobulin G Subclass Deficiency

Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Necrotizing Gastritis

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor	Hematopoietic Neoplasm Of Central Nervous System
Central Nervous System Hematopoietic Neoplasm

Central Nervous System Lymphoma

Microglioma	Primary Cns Lymphoma
Cns Lymphoma	Primary Central Nervous System Lymphoma

Penis Carcinoma In Situ

Carcinoma In Situ Of Penis	Bowen'S Disease Of Penis
Grade Iii Squamous Intraepithelial Lesion Of Penis	Penile Intraepithelial Neoplasia Grade Iii
Queyrat'S Erythroplasia	Erythroplasia Of Queyrat
Pin - [Penile Intraepithelial Neoplasia]

Uterine Body Mixed Cancer

Malignant Mixed Tumor Of Corpus Uteri

Malignant Mixed Tumor, Not Otherwise Specified

Endocervical Carcinoma

Carcinoma Of Endocervix

Carcinoma Of The Endocervix

Refractory Plasma Cell Neoplasm

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10190	PDCD1LG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDCD1LG2	VGNC	VGNC:56980
Rattus norvegicus	PDCD1LG2	RGD	RGD:1306403
Canis familiaris	PDCD1LG2	VGNC	VGNC:44336
Mus musculus	PDCD1LG2	MGD	MGI:1930125
Felis catus	PDCD1LG2	VGNC	VGNC:64078
Macaca mulatta	PDCD1LG2	VGNC	VGNC:75645
Macaca fascicularis	PDCD1LG2	NCBI	NCBI:102146227
Others	PDCD1LG2	NCBI

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