SETD7 - SET domain containing 7, histone lysine methyltransferase Gene

Homo sapiens

Also known as KMT7; SET7; SET9; SET7/9

Gene ID: 80854 | Gene type: protein coding

About SETD7

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,492,974-139,556,219 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 22.9), prostate (RPKM 16.7) and 24 other tissues.

Summary

Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response to DNA damage stimulus and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

SETD7 Products(3)

mRNA	Protein	Name
NM_001306199.2	NP_001293128.1	histone-lysine N-methyltransferase SETD7 isoform 2
NM_001306200.2	NP_001293129.1	histone-lysine N-methyltransferase SETD7 isoform 3
NM_030648.4	NP_085151.1	histone-lysine N-methyltransferase SETD7 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3 methyltransferase activity	IDA IDA: Inferred from direct assay	16415881	GOA
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	17707234	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	17108971	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12540855	GOA
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	16415881	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	23509280	GOA
acts upstream of or within heterochromatin organization	IDA IDA: Inferred from direct assay	23509280	GOA
involved in peptidyl-lysine dimethylation	IDA IDA: Inferred from direct assay	17108971	GOA
involved in peptidyl-lysine monomethylation	IDA IDA: Inferred from direct assay	17108971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SETD7 Protein Structure

MORN

SET

0
100
200
300
366 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase SETD7

H3-K4-HMTase SETD7

SETD7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SETD7	Q8WTS6	SIRT1	Homo sapiens	Q96EB6	Methyltransferase Ass	21245319
Intra	SETD7	Q8WTS6	SIRT1	Homo sapiens	Q96EB6	Pull Down	21245319
Intra	SETD7	Q8WTS6	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	21245319
Intra	SETD7	Q8WTS6	TP53	Homo sapiens	P04637	Radiolabeled Methyl	16415881
Intra	SETD7	Q8WTS6	TP53	Homo sapiens	P04637	Methyltransferase Ass	17805299
Intra	SETD7	Q8WTS6	TP53	Homo sapiens	P04637	Methyltransferase Ass	21245319
Intra	SETD7	Q8WTS6	TP53	Homo sapiens	P04637	Pull Down	21245319
Intra	SETD7	Q8WTS6	RB1	Homo sapiens	P06400	Methyltransferase Ass	21119616
Intra	SETD7	Q8WTS6	TAF10	Homo sapiens	Q12962	X-Ray Diffraction	16415881
Intra	SETD7	Q8WTS6	TAF10	Homo sapiens	Q12962	Radiolabeled Methyl	16415881
Intra	SETD7	Q8WTS6	DNMT1	Homo sapiens	P26358	Methyltransferase Ass	19282482
Intra	SETD7	Q8WTS6	DNMT1	Homo sapiens	P26358	Pull Down	19282482
Intra	SETD7	Q8WTS6	RELA	Homo sapiens	Q04206	Methyltransferase Ass	19262565
Intra	SETD7	Q8WTS6	RELA	Homo sapiens	Q04206	Anti Tag CoIP	19262565
Intra	SETD7	Q8WTS6	RELA	Homo sapiens	Q04206	Pull Down	19262565
Intra	SETD7	Q8WTS6	RELA	Homo sapiens	Q04206	Anti Bait CoIP	19262565
Intra	SETD7	Q8WTS6	SERTAD1	Homo sapiens	Q9UHV2	Y2H	21988832
Intra	SETD7	Q8WTS6	H3C1	Homo sapiens	P68431	X-Ray Diffraction	12540855

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SETD7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76062	SETD7 Protein, Human (His)	Q8WTS6/NP_085151.1 (D2-K366)	≥95%

SETD7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83151	SETD7 Antibody (YA2896)	WB, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18627A	PFI-2 hydrochloride	Inhibitor	99.52%	Unkown
HY-13807	UNC0646	Inhibitor	99.38%	Unkown
HY-148817	WDR5-0102	Inhibitor	97.02%	Unkown
HY-18627	PFI-2	Inhibitor	/	Unkown
HY-110196	(S)-PFI-2 hydrochloride	Inhibitor	/	Unkown
HY-156455	SETD7-IN-1	Inhibitor	/	Unkown
HY-RS12747	SETD7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SETD7	VGNC	VGNC:46058
Rattus norvegicus	SETD7	RGD	RGD:1586346
Mus musculus	SETD7	MGD	MGI:1920501
Bos taurus	SETD7	VGNC	VGNC:34497
Felis catus	SETD7	VGNC	VGNC:65046
Macaca mulatta	SETD7	VGNC	VGNC:77348
Others	SETD7	NCBI

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