ANP32A - acidic nuclear phosphoprotein 32 family member A Gene

Homo sapiens

Also known as LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1

Gene ID: 8125 | Gene type: protein coding

About ANP32A

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,778,535-68,820,895 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 45.8), bone marrow (RPKM 40.5) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ANP32A Products(1)

mRNA	Protein	Name
NM_006305.4	NP_006296.1	acidic leucine-rich nuclear phosphoprotein 32 family member A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	11729309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11729309	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	11555662	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11555662	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11555662	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANP32A Protein Structure

LRR_9

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

acidic leucine-rich nuclear phosphoprotein 32 family member A

acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

ANP32A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANP32A	P39687	E4F1	Homo sapiens	Q66K89	Imaging	17557114
Intra	ANP32A	P39687	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	21806989
Intra	ANP32A	P39687	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	ANP32A	P39687	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ANP32A	P39687	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Cross	ANP32A	P39687	Ppp2ca	Rattus norvegicus	P63331	Pull Down	21806989

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANP32A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76150	ANP32A Protein, Human (His)	P39687 (E2-K238)	≥95%

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1	SCA1
Olivopontocerebellar Atrophy I	Opca1
Opca4	Menzel Type Opca
Schut-Haymaker Type Opca	Spinocerebellar Atrophy I
Opca I	Olivopontocerebellar Atrophy Iv
Opca Iv	Cerebelloparenchymal Disorder I
Cpd1	Olivopontocerebellar Atrophy 1
Cerebelloparenchymal Disorder 1	Olivopontocerebellar Atrophy 4
Spinocerebellar Atrophy 1	Type 1 Spinocerebellar Ataxia
Spinocerebellar Ataxia-1	Ataxia, Spinocerebellar, Type 1

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Primary Cerebellar Degeneration

Spinocerebellar Degenerations	Cerebellar Degenerations, Primary
Spinocerebellar Degeneration

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung	Squamous Cell Lung Carcinoma
Epidermoid Cell Carcinoma Of The Lung	Squamous Cell Lung Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00751	ANP32A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ANP32A	RGD	RGD:11508551
Mus musculus	ANP32A	MGD	MGI:108447
Macaca mulatta	ANP32A	VGNC	VGNC:84302
Others	ANP32A	NCBI

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