AKAP17A - A-kinase anchoring protein 17A Gene

Homo sapiens

Also known as XE7; 721P; XE7Y; CCDC133; CXYorf3; PRKA17A; SFRS17A; AKAP-17A; DXYS155E

Gene ID: 8227 | Gene type: protein coding

About AKAP17A

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,591,604-1,602,520 (from NCBI)

This gene has 3 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in spleen (RPKM 26.3), bone marrow (RPKM 23.0) and 25 other tissues.

Summary

This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]

AKAP17A Products(1)

mRNA	Protein	Name
NM_005088.3	NP_005079.2	A-kinase anchor protein 17A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16982639	GOA
enables protein kinase A binding	IDA IDA: Inferred from direct assay	19840947	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	19840947	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	16982639	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19840947	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 17A

A kinase (PRKA) anchor protein 17A

Related Diseases

Diseases

Alias

Null-Cell Leukemia

Null Cell Acute Lymphoblastic Leukemia	Null Cell Acute Lymphoblastic Leukaemia
Null-Cell Leukaemia

Corneal Dystrophy, Posterior Polymorphous, 2

Posterior Polymorphous Corneal Dystrophy 2	PPCD2
Corneal Dystrophy, Posterior Polymorphous 2	Corneal Dystrophy Polymorphous Posterior, 2
Dystrophy, Corneal, Posterior Polymorphous, Type 2

Hodgkin'S Lymphoma, Mixed Cellularity

Hodgkin'S Disease, Mixed Cellularity	Hodgkins Lymphoma, Mixed Cellularity
Mixed Cellularity Hodgkin Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00517	AKAP17A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKAP17A	RGD	RGD:1564640
Macaca mulatta	AKAP17A	VGNC	VGNC:69633
Mus musculus	AKAP17A	MGD	MGI:2443758
Bos taurus	AKAP17A	VGNC	VGNC:106636

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