BRAP - BRCA1 associated protein Gene

Homo sapiens

Also known as IMP; BRAP2; RNF52

Gene ID: 8315 | Gene type: protein coding

About BRAP

Cytogenetic location: 12q24.12 Genomic coordinates (GRCh38): 12:111,642,146-111,685,956 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 24.8), bone marrow (RPKM 8.8) and 24 other tissues.

Summary

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

BRAP Products(1)

mRNA	Protein	Name
NM_006768.5	NP_006759.3	BRCA1-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	14724641	GOA
enables nuclear localization sequence binding	IDA IDA: Inferred from direct assay	9497340	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9497340	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14724641	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14724641	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	14724641	GOA
acts upstream of or within Ras protein signal transduction	IDA IDA: Inferred from direct assay	14724641	GOA
involved in negative regulation of signal transduction	IDA IDA: Inferred from direct assay	14724641	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14724641	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9497340	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14724641	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRAP Protein Structure

BRAP2

zf-RING_2

zf-UBP

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

BRCA1-associated protein

RING finger protein 52

Related Diseases

Diseases

Alias

Astereognosia

Somatosensory Agnosia

Tactile Agnosia

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01591	BRAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BRAP	RGD	RGD:1586551
Bos taurus	BRAP	VGNC	VGNC:26552
Mus musculus	BRAP	MGD	MGI:1919649
Canis familiaris	BRAP	VGNC	VGNC:38515
Felis catus	BRAP	VGNC	VGNC:60163
Macaca mulatta	BRAP	VGNC	VGNC:70278
Others	BRAP	NCBI

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