CASP2 - caspase 2 Gene

Homo sapiens

Also known as ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57

Gene ID: 835 | Gene type: protein coding

About CASP2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,288,351-143,307,696 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 14.7), lymph node (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Caspases mediate cellular Apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

CASP2 Products(4)

mRNA	Protein	Name
NM_032982.4	NP_116764.2	caspase-2 isoform 1 preproprotein
NM_032984.2
NM_001224.5	NP_001215.1	caspase-2 isoform 2
NM_032983.4	NP_116765.2	caspase-2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	9044836	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22531785	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8985253	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9044836	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: Inferred from mutant phenotype	21726810	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10980123	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	9044836	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of endopeptidase complex	IPI IPI: Inferred from physical interaction	15073321	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP2 Protein Structure

CARD

Peptidase_C14

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

caspase-2

caspase 2 apoptosis-related cysteine peptidase	neural precursor cell expressed developmentally down-regulated protein 2
protease ICH-1	protein phosphatase 1, regulatory subunit 57

CASP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CASP2	P42575	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	CASP2	P42575	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Validated Y2H	25416956
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Affinity Chrom	15073321
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	CoIP	8985253
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Validated Y2H	32296183
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Y2H Array	25416956
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Anti Bait CoIP	16652156
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	MAPPIT	31467278
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	BRET	37398436
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Complementation	31467278
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Validated Y2H	27107012
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Y2H Array	31467278
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Lumier	37398436
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Anti Tag CoIP	15073321
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Y2H Prey Pooling	25416956
Intra	CASP2	P42575	CASP2	Homo sapiens	P42575-1	Anti Tag CoIP	11156409

Cross: Cross-species interaction Intra: Intraspecies interaction

CASP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83027	Cleaved-Caspase 2 Antibody (YA2772)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy	Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To
NAION	Non-Arteritic Anterior Ischemic Optic Neuropathy
Ischemic Optic Neuropathy	Aion
Optic Neuropathy, Ischemic	Naion, Susceptibility To
Optic Neuropathy, Anterior Ischemic	Optic Neuropathy, Anterior Ischemic, Susceptibility To
Non-Arteritic Anterior Ischaemic Optic Neuropathy	Nonarteritic Anterior Ischaemic Optic Neuropathy
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To	Ion - [Ischemic Optic Neuropathy]
Neuropathic Ischaemia Of N.Opticus	Ischaemic Neuropathy Of Optic Nerve

Bladder Transitional Cell Papilloma

Bladder Papilloma	Transitional Cell Papilloma Of Bladder
Urinary Bladder Urothelial Papilloma	Urothelial Papilloma
Bladder Urothelial Papilloma

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-RS01949	CASP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01950	Casp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01951	Casp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CASP2	VGNC	VGNC:60381
Macaca mulatta	CASP2	VGNC	VGNC:80804
Bos taurus	CASP2	VGNC	VGNC:26780
Canis familiaris	CASP2	VGNC	VGNC:38733
Rattus norvegicus	CASP2	RGD	RGD:69274
Mus musculus	CASP2	MGD	MGI:97295

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