KBTBD7 - kelch repeat and BTB domain containing 7 Gene

Homo sapiens

Gene ID: 84078 | Gene type: protein coding

About KBTBD7

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,189,834-41,194,569 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 54 paralogues.

Summary

The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]

KBTBD7 Products(1)

mRNA	Protein	Name
NM_032138.7	NP_115514.2	kelch repeat and BTB domain-containing protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25684205	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	25684205	GOA
involved in regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	25684205	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	25684205	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KBTBD7 Protein Structure

BTB

BACK

Kelch_1

0
200
400
600
684 a.a.

Protein Preferred Names

Protein Names

kelch repeat and BTB domain-containing protein 7

kelch repeat and BTB (POZ) domain containing 7

KBTBD7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KBTBD7	Q8WVZ9	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KBTBD7	Q8WVZ9	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KBTBD7	Q8WVZ9	KBTBD8	Homo sapiens	Q8NFY9	Anti Tag CoIP	28514442
Intra	KBTBD7	Q8WVZ9	KBTBD8	Homo sapiens	Q8NFY9	Anti Tag CoIP	33961781
Intra	KBTBD7	Q8WVZ9	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	KBTBD7	Q8WVZ9	MAP1LC3C	Homo sapiens	Q9BXW4	ITC	25684205
Intra	KBTBD7	Q8WVZ9	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32296183
Intra	KBTBD7	Q8WVZ9	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32296183
Intra	KBTBD7	Q8WVZ9	KLF15	Homo sapiens	Q9UIH9	Y2H Prey Pooling	32296183
Intra	KBTBD7	Q8WVZ9	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	KBTBD7	Q8WVZ9	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	KBTBD7	Q8WVZ9	MAP1LC3B	Homo sapiens	Q9GZQ8	ITC	25684205
Intra	KBTBD7	Q8WVZ9	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	KBTBD7	Q8WVZ9	MAP1LC3B	Homo sapiens	Q9GZQ8	Y2H	21900206
Intra	KBTBD7	Q8WVZ9	CCDC106	Homo sapiens	Q9BWC9	Y2H Prey Pooling	32296183
Intra	KBTBD7	Q8WVZ9	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	32296183
Intra	KBTBD7	Q8WVZ9	CCDC106	Homo sapiens	Q9BWC9	Y2H Array	32296183
Intra	KBTBD7	Q8WVZ9	GABARAP	Homo sapiens	O95166	Anti Tag CoIP	25684205
Intra	KBTBD7	Q8WVZ9	GABARAP	Homo sapiens	O95166	ITC	25684205
Intra	KBTBD7	Q8WVZ9	GABARAP	Homo sapiens	O95166	Peptide Array	25684205
Intra	KBTBD7	Q8WVZ9	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	KBTBD7	Q8WVZ9	PHC2	Homo sapiens	Q8IXK0	Y2H Prey Pooling	25416956
Intra	KBTBD7	Q8WVZ9	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	KBTBD7	Q8WVZ9	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	25684205
Intra	KBTBD7	Q8WVZ9	GABARAPL2	Homo sapiens	P60520	Y2H	21900206
Intra	KBTBD7	Q8WVZ9	GABARAPL2	Homo sapiens	P60520	ITC	25684205
Intra	KBTBD7	Q8WVZ9	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	KBTBD7	Q8WVZ9	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	25684205
Intra	KBTBD7	Q8WVZ9	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	25416956
Intra	KBTBD7	Q8WVZ9	GABARAPL1	Homo sapiens	Q9H0R8	ITC	25684205

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07095	KBTBD7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KBTBD7	VGNC	VGNC:56746
Felis catus	KBTBD7	VGNC	VGNC:102238
Macaca mulatta	KBTBD7	VGNC	VGNC:73903
Bos taurus	KBTBD7	VGNC	VGNC:53820
Mus musculus	KBTBD7	MGD	MGI:2685141
Rattus norvegicus	KBTBD7	RGD	RGD:6501695
Others	KBTBD7	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.