UXT - ubiquitously expressed prefoldin like chaperone Gene

Homo sapiens

Also known as STAP1; ART-27

Gene ID: 8409 | Gene type: protein coding

About UXT

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,651,796-47,659,180 (from NCBI)

This gene has 5 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in bone marrow (RPKM 37.8), ovary (RPKM 37.2) and 25 other tissues.

Summary

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced Apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

UXT Products(2)

mRNA	Protein	Name
NM_004182.4	NP_004173.1	protein UXT isoform 2
NM_153477.3	NP_705582.1	protein UXT isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables actin filament binding	IDA IDA: Inferred from direct assay	12762840	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	12762840	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	21730289	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12762840	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	21730289	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	16221885	GOA
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16221885	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21730289	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RPAP3/R2TP/prefoldin-like complex	IPI IPI: Inferred from physical interaction	31738558	GOA
located in centrosome	IDA IDA: Inferred from direct assay	16221885	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21730289	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	12762840	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12762840	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UXT Protein Structure

Prefoldin

0
100
157 a.a.

Protein Preferred Names

Protein Names

protein UXT

SKP2-associated alpha PFD 1

UXT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UXT	Q9UBK9	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	UXT	Q9UBK9	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	UXT	Q9UBK9	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	UXT	Q9UBK9	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	UXT	Q9UBK9	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	UXT	Q9UBK9	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	UXT	Q9UBK9	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	UXT	Q9UBK9	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	UXT	Q9UBK9	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	UXT	Q9UBK9	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	UXT	Q9UBK9	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	UXT	Q9UBK9	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	MECOM	Homo sapiens	Q03112	Y2H	17635584
Intra	UXT	Q9UBK9	MECOM	Homo sapiens	Q03112	Pull Down	17635584
Intra	UXT	Q9UBK9	MECOM	Homo sapiens	Q03112	Anti Tag CoIP	17635584
Intra	UXT	Q9UBK9	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	UXT	Q9UBK9	RPAP3	Homo sapiens	Q9H6T3	Anti Tag CoIP	33961781
Intra	UXT	Q9UBK9	RPAP3	Homo sapiens	Q9H6T3	Lumier	25036637
Intra	UXT	Q9UBK9	PFDN2	Homo sapiens	Q9UHV9	Lumier	25036637
Intra	UXT	Q9UBK9	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	UXT	Q9UBK9	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17620405
Intra	UXT	Q9UBK9	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	25416956
Intra	UXT	Q9UBK9	PAK5	Homo sapiens	Q9P286	Y2H Array	31515488
Intra	UXT	Q9UBK9	PAK5	Homo sapiens	Q9P286	Y2H Array	25416956
Intra	UXT	Q9UBK9	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	UXT	Q9UBK9	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	UXT	Q9UBK9	SARM1	Homo sapiens	Q0D2N8	Y2H	24021647
Intra	UXT	Q9UBK9	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	UXT	Q9UBK9	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	UXT	Q9UBK9	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	UXT	Q9UBK9	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15591	UXT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UXT	VGNC	VGNC:36754
Felis catus	UXT	VGNC	VGNC:66910
Rattus norvegicus	UXT	RGD	RGD:1359326
Macaca mulatta	UXT	VGNC	VGNC:103884
Canis familiaris	UXT	VGNC	VGNC:48221
Mus musculus	UXT	MGD	MGI:1277988

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