2. Gene
  3. PRAM1 - PML-RARA regulated adaptor molecule 1 Gene

PRAM1 - PML-RARA regulated adaptor molecule 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRAM-1; PML-RAR

Gene ID: 84106 | Gene type: protein coding

About PRAM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,490,056-8,502,640 (from NCBI)

This gene has 4 transcripts (splice variants), 145 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues.

Summary

The protein encoded by this gene is similar to Fyn binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

PRAM1 Products(1)

mRNA Protein Name
NM_032152.5 NP_115528.4 PML-RARA-regulated adapter molecule 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21163940 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20873783 GOA
Cellular Component GO Annotation Evidence Reference Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRAM1 Protein Structure

hSH3

hSH3: Helically-extended SH3 domain (576 - 655)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

PML-RARA-regulated adapter molecule 1

PML-RARA target gene encoding an Adaptor Molecule-1

PRAM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PRAM1 Q96QH2 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra PRAM1 Q96QH2 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra PRAM1 Q96QH2 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra PRAM1 Q96QH2 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra PRAM1 Q96QH2 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra PRAM1 Q96QH2 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra PRAM1 Q96QH2 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra PRAM1 Q96QH2 NEDD9 Homo sapiens Q14511-2
Y2H Array
32296183
Intra PRAM1 Q96QH2 NEDD9 Homo sapiens Q14511-2
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra PRAM1 Q96QH2 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 SKAP1 Homo sapiens Q86WV1-2
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 SKAP1 Homo sapiens Q86WV1-2
Y2H Array
32296183
Intra PRAM1 Q96QH2 SKAP1 Homo sapiens Q86WV1
Y2H Array
31515488
Intra PRAM1 Q96QH2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra PRAM1 Q96QH2 BCAR1 Homo sapiens P56945
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 BCAR1 Homo sapiens P56945
Y2H Array
32296183
Intra PRAM1 Q96QH2 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra PRAM1 Q96QH2 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra PRAM1 Q96QH2 RNF32 Homo sapiens Q9H0A6
Y2H Array
21163940
Intra PRAM1 Q96QH2 RNF32 Homo sapiens Q9H0A6
Pull Down
21163940
Intra PRAM1 Q96QH2 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra PRAM1 Q96QH2 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra PRAM1 Q96QH2 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Array
25416956
Intra PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11048 PRAM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRAM1 MGD MGI:3576625
Canis familiaris PRAM1 VGNC VGNC:44940
Bos taurus PRAM1 VGNC VGNC:33284
Rattus norvegicus PRAM1 RGD RGD:1564330
Macaca mulatta PRAM1 VGNC VGNC:76344