BCAR3 - BCAR3 adaptor protein, NSP family member Gene

Homo sapiens

Also known as MIG7; NSP2; AND-34; SH2D3B

Gene ID: 8412 | Gene type: protein coding

About BCAR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,561,741-93,847,219 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues.

Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast Cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast Cancer cells. The protein contains a putative Src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BCAR3 Products(33)

mRNA	Protein	Name
NM_001261408.2	NP_001248337.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261409.1	NP_001248338.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261410.2	NP_001248339.1	breast cancer anti-estrogen resistance protein 3 isoform 2
NM_001308251.1	NP_001295180.1	breast cancer anti-estrogen resistance protein 3 isoform 3
NM_001412043.1	NP_001398972.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412044.1	NP_001398973.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412045.1	NP_001398974.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412046.1	NP_001398975.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412048.1	NP_001398977.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412049.1	NP_001398978.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412050.1	NP_001398979.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412051.1	NP_001398980.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412052.1	NP_001398981.1	breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412054.1	NP_001398983.1	breast cancer anti-estrogen resistance protein 3 isoform 4
NM_001412055.1	NP_001398984.1	breast cancer anti-estrogen resistance protein 3 isoform 5
NM_001412056.1	NP_001398985.1	breast cancer anti-estrogen resistance protein 3 isoform 6
NM_001412057.1	NP_001398986.1	breast cancer anti-estrogen resistance protein 3 isoform 7
NM_001412058.1	NP_001398987.1	breast cancer anti-estrogen resistance protein 3 isoform 8
NM_001412059.1	NP_001398988.1	breast cancer anti-estrogen resistance protein 3 isoform 9
NM_001412060.1	NP_001398989.1	breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412061.1	NP_001398990.1	breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412062.1	NP_001398991.1	breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412064.1	NP_001398993.1	breast cancer anti-estrogen resistance protein 3 isoform 12
NM_001412065.1	NP_001398994.1	breast cancer anti-estrogen resistance protein 3 isoform 13
NM_001412066.1	NP_001398995.1	breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412067.1	NP_001398996.1	breast cancer anti-estrogen resistance protein 3 isoform 15
NM_001412072.1	NP_001399001.1	breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412073.1	NP_001399002.1	breast cancer anti-estrogen resistance protein 3 isoform 16
NM_001412074.1	NP_001399003.1	breast cancer anti-estrogen resistance protein 3 isoform 17
NM_001412075.1	NP_001399004.1	breast cancer anti-estrogen resistance protein 3 isoform 18
NM_001412076.1	NP_001399005.1	breast cancer anti-estrogen resistance protein 3 isoform 19
NM_001412077.1	NP_001399006.1	breast cancer anti-estrogen resistance protein 3 isoform 8
NM_003567.4	NP_003558.1	breast cancer anti-estrogen resistance protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	18722344	GOA
enables phosphotyrosine residue binding	IMP IMP: Inferred from mutant phenotype	24216110	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endothelin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19086031	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18722344	GOA
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24216110	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19086031	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	24216110	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18722344	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAR3 Protein Structure

SH2

RasGEF

0
200
400
600
825 a.a.

Protein Preferred Names

Protein Names

breast cancer anti-estrogen resistance protein 3

BCAR3, NSP family adaptor protein

Related Diseases

Diseases

Alias

Estrogen Resistance

Estrogen Resistance Syndrome	ESTRR
Estrogen Insensitivity

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01398	BCAR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BCAR3	VGNC	VGNC:70235
Mus musculus	BCAR3	MGD	MGI:1352501
Felis catus	BCAR3	VGNC	VGNC:69195
Canis familiaris	BCAR3	VGNC	VGNC:49077
Rattus norvegicus	BCAR3	RGD	RGD:1311688
Bos taurus	BCAR3	VGNC	VGNC:53850

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