2. Gene
  3. SARNP - SAP domain containing ribonucleoprotein Gene

SARNP - SAP domain containing ribonucleoprotein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HCC1; THO1; CIP29; HSPC316

Gene ID: 84324 | Gene type: protein coding

About SARNP

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,752,463-55,817,724 (from NCBI)

This gene has 6 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 27.2), endometrium (RPKM 26.0) and 25 other tissues.

Summary

This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

SARNP Products(1)

mRNA Protein Name
NM_033082.4 NP_149073.1 SAP domain-containing ribonucleoprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
20844015 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
20844015 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
20844015 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARNP Protein Structure

SAP

SAP: SAP domain (8 - 42)

  • 0
  • 100
  • 210 a.a.
Protein Preferred Names Protein Names

SAP domain-containing ribonucleoprotein

cytokine induced protein 29 kDa

SARNP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SARNP P82979 DDX39A Homo sapiens O00148
Anti Tag CoIP
33961781
Intra
SARNP P82979 DDX39A Homo sapiens O00148
Y2H Array
25416956
Intra
SARNP P82979 DDX39A Homo sapiens O00148
Y2H Prey Pooling
25416956
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Y2H Prey Pooling
32296183
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Anti Tag CoIP
33961781
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Validated Y2H
32296183
Intra
SARNP P82979 DDX39B Homo sapiens Q13838
Y2H Array
32296183
Intra
SARNP P82979 U2AF1 Homo sapiens Q01081
FRET
18559666
Intra
SARNP P82979 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SARNP P82979 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SARNP P82979 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SARNP P82979 U2AF2 Homo sapiens P26368
FRET
18559666
Intra
SARNP P82979 U2AF2 Homo sapiens P26368
Anti Bait CoIP
18559666
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Myelomonocytic Leukemia

Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

16)(P13

Q22)

Aml M4

Ammol

Acute Myeloblastic Leukemia Type 4

Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

16)(P13

Q22)

Aml-M4

Aml With Inv(16)(P13.1q22) Or T(16

16)(P13.1

Q22)

Cbfb-Myh11

Leukemia Myelomonocytic Acute

Leukemia, Myelomonocytic, Acute

Acute Myelomonocytic Leukaemia Without Mention Of Remission

Myelomonocytic Leukaemia Nos
Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

Eec Syndrome

Rudiger Syndrome 1

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1

EEC1

Eec Syndrome 1

Eec Syndrome-1

Walker-Clodius Syndrome

Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome

Eec

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome

Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

Ectrodactyly-Cleft Lip/Palate Syndrome

Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate

Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome

Ectrodactyly-Cleft Lip-Palate Syndrome

Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Superficial Urinary Bladder Cancer

Superficial Urinary Bladder Carcinoma

Carcinoma Of Urinary Bladder, Superficial
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12447 SARNP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SARNP RGD RGD:1305692
Canis familiaris SARNP VGNC VGNC:54543
Mus musculus SARNP MGD MGI:1913368