DDX39A - DExD-box helicase 39A Gene

Homo sapiens

Also known as BAT1; DDXL; BAT1L; DDX39; URH49

Gene ID: 10212 | Gene type: protein coding

About DDX39A

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,408,798-14,419,383 (from NCBI)

This gene has 21 transcripts (splice variants), 283 orthologues and 38 paralogues. Broad expression in testis (RPKM 59.3), bone marrow (RPKM 58.2) and 24 other tissues.

Summary

This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

DDX39A Products(1)

mRNA	Protein	Name
NM_005804.4	NP_005795.2	ATP-dependent RNA helicase DDX39A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	EXP EXP: Inferred from Experiment	20844015	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA export from nucleus	IGI IGI: Inferred from genetic interaction	15047853	GOA
involved in mRNA splicing, via spliceosome	IGI IGI: Inferred from genetic interaction	15047853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	21859714	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21859714	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX39A Protein Structure

DEAD

Helicase_C

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DDX39A

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A

DDX39A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX39A	O00148	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	DDX39A	O00148	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	DDX39A	O00148	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	DDX39A	O00148	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
Intra	DDX39A	O00148	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	DDX39A	O00148	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
Intra	DDX39A	O00148	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	DDX39A	O00148	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	DDX39A	O00148	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	DDX39A	O00148	SARNP	Homo sapiens	P82979	Validated Y2H	25416956
Intra	DDX39A	O00148	SARNP	Homo sapiens	P82979	Y2H Pooling	16189514
Intra	DDX39A	O00148	ccsb_9919	Homo sapiens	EBI-25847655	Y2H Array	32814053
Intra	DDX39A	O00148	DDX39B	Homo sapiens	Q13838	Validated Y2H	32296183
Intra	DDX39A	O00148	DDX39B	Homo sapiens	Q13838	Anti Tag CoIP	33961781
Intra	DDX39A	O00148	DDX39B	Homo sapiens	Q13838	Y2H Prey Pooling	32296183
Intra	DDX39A	O00148	DDX39A	Homo sapiens	O00148	Y2H Prey Pooling	32296183
Intra	DDX39A	O00148	DDX39B	Homo sapiens	Q13838	Y2H Array	32296183
Intra	DDX39A	O00148	DDX39A	Homo sapiens	O00148	Y2H Array	25416956
Intra	DDX39A	O00148	ccsb_9919	Homo sapiens	EBI-25847655	Y2H Pooling	32814053
Intra	DDX39A	O00148	DDX39A	Homo sapiens	O00148	Y2H Array	32296183
Intra	DDX39A	O00148	ccsb_9919	Homo sapiens	EBI-25847655	Validated Y2H	32814053
Intra	DDX39A	O00148	DDX39A	Homo sapiens	O00148	Validated Y2H	32296183
Intra	DDX39A	O00148	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	DDX39A	O00148	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	DDX39A	O00148	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	DDX39A	O00148	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	DDX39A	O00148	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	DDX39A	O00148	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	DDX39A	O00148	h0yhg0_human	Homo sapiens	H0YHG0	Y2H Array	25416956
Intra	DDX39A	O00148	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	DDX39A	O00148	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	25416956
Intra	DDX39A	O00148	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DDX39A	O00148	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	DDX39A	O00148	WFS1	Homo sapiens	O76024	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hairy Tongue

Overgrowth Of Filiform Papillae

Tongue, Hairy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03644	DDX39A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DDX39A	VGNC	VGNC:27964
Felis catus	DDX39A	VGNC	VGNC:61406
Canis familiaris	DDX39A	VGNC	VGNC:39854
Mus musculus	DDX39A	MGD	MGI:1915528
Macaca mulatta	DDX39A	VGNC	VGNC:71651
Rattus norvegicus	DDX39A	RGD	RGD:619920

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