CUL4A - cullin 4A Gene

Homo sapiens

Gene ID: 8451 | Gene type: protein coding

About CUL4A

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,208,193-113,267,108 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.5), heart (RPKM 17.9) and 25 other tissues.

Summary

CUL4A is the ubiquitin Ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

CUL4A Products(11)

mRNA	Protein	Name
NM_001008895.4	NP_001008895.1	cullin-4A isoform 1
NM_001278513.3	NP_001265442.1	cullin-4A isoform 2
NM_001278514.3	NP_001265443.1	cullin-4A isoform 3
NM_001354938.2	NP_001341867.1	cullin-4A isoform 2
NM_001354939.2	NP_001341868.1	cullin-4A isoform 2
NM_001354940.2	NP_001341869.1	cullin-4A isoform 2
NM_001354941.2	NP_001341870.1	cullin-4A isoform 4
NM_001354942.2	NP_001341871.1	cullin-4A isoform 4
NM_001354943.2	NP_001341872.1	cullin-4A isoform 5
NM_001354944.2	NP_001341873.1	cullin-4A isoform 6
NM_003589.4	NP_003580.1	cullin-4A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12504025	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	34065512	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	20870715	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	11027288	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	EXP EXP: Inferred from Experiment	22118460	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	34065512	GOA
involved in cellular response to UV	EXP EXP: Inferred from Experiment	22118460	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	11027288	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	14739464	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	26431207	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	28437394	GOA
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	26711351	GOA
involved in spermatogenesis	IDA IDA: Inferred from direct assay	34065512	GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	34065512	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	EXP EXP: Inferred from Experiment	22118460	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12732143	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	34065512	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	10585395	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL4A Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
759 a.a.

Protein Preferred Names

Protein Names

cullin-4A

CUL-4A

CUL4A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CUL4A	Q13619	DDB2	Homo sapiens	Q92466	Anti Bait CoIP	17041588
Intra	CUL4A	Q13619	DDB2	Homo sapiens	Q92466	Anti Tag CoIP	30945288
Intra	CUL4A	Q13619	DDB2	Homo sapiens	Q92466	TAP	21145461
Intra	CUL4A	Q13619	UBXN7	Homo sapiens	O94888	Anti Tag CoIP	22466964
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	30945288
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	TAP	21145461
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	Anti Bait CoIP	17041588
Intra	CUL4A	Q13619	DDB1	Homo sapiens	Q16531	Pull Down	22157821
Intra	CUL4A	Q13619	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	CUL4A	Q13619	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL4A	Q13619	VCP	Homo sapiens	P55072	Anti Tag CoIP	22466964
Intra	CUL4A	Q13619	CAND1	Homo sapiens	Q86VP6	CoIP	12609982
Intra	CUL4A	Q13619	CAND1	Homo sapiens	Q86VP6	Anti Bait CoIP	12504026
Intra	CUL4A	Q13619	CAND1	Homo sapiens	Q86VP6	TAP	21145461

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E	Xeroderma Pigmentosum V
Xp Group E	Xp5
Xpe	Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C	XPC
Xpcc	Xeroderma Pigmentosum Iii
Xp3	Xeroderma Pigmentosum Group C
Xp Group C	Xp, Group C
Xeroderma Pigmentosum, Type 3	Xeroderma Pigmentosum Complementation Group C
XP-C

Childhood Medulloblastoma

Medulloblastoma, Childhood	Pediatric Medulloblastoma
Medulloblastoma Childhood

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

De Sanctis-Cacchione Syndrome

Xerodermic Idiocy	Xeroderma Pigmentosum With Neurologic Manifestation
DSC	Xerodermic Idiocy Of De Sanctis And Cacchione

Uv-Sensitive Syndrome

Uvss	Uv Sensitive Syndrome
Ultraviolet Sensitive Syndrome

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148602	KH-4-43		99.99%	Unkown
HY-161166	MM-02-57		/	Unkown
HY-RS03362	CUL4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CUL4A	VGNC	VGNC:27832
Rattus norvegicus	CUL4A	RGD	RGD:1563853
Mus musculus	CUL4A	MGD	MGI:1914487
Macaca mulatta	CUL4A	VGNC	VGNC:71568
Felis catus	CUL4A	VGNC	VGNC:97394
Canis familiaris	CUL4A	VGNC	VGNC:39731
Others	CUL4A	NCBI

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