2. Gene
  3. TEAD2 - TEA domain transcription factor 2 Gene

TEAD2 - TEA domain transcription factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ETF; TEF4; TEF-4; TEAD-2

Gene ID: 8463 | Gene type: protein coding

About TEAD2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,340,595-49,362,416 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Apr 2022]

TEAD2 Products(6)

mRNA Protein Name
NM_001256658.2 NP_001243587.1 transcriptional enhancer factor TEF-4 isoform 1
NM_001256659.2 NP_001243588.1 transcriptional enhancer factor TEF-4 isoform 1
NM_001256660.2 NP_001243589.1 transcriptional enhancer factor TEF-4 isoform 2
NM_001256661.2 NP_001243590.1 transcriptional enhancer factor TEF-4 isoform 2
NM_001256662.2 NP_001243591.1 transcriptional enhancer factor TEF-4 isoform 4
NM_003598.2 NP_003589.1 transcriptional enhancer factor TEF-4 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18579750 GOA
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
20368466 GOA
enables disordered domain specific binding IMP
IMP: Inferred from mutant phenotype
20368466 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18579750 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
20368466 GOA
Biological Process GO Annotation Evidence Reference Source
involved in hippo signaling IDA
IDA: Inferred from direct assay
18579750 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20368466 GOA
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
20368466 GOA
Cellular Component GO Annotation Evidence Reference Source
part of TEAD-YAP complex IDA
IDA: Inferred from direct assay
20368466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD2 Protein Structure

TEA

TEA: TEA/ATTS domain family (20 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-4

TEA domain family member 2

TEAD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TEAD2 Q15562 BCL2L15 Homo sapiens Q5TBC7
Anti Tag CoIP
25416956
Intra
TEAD2 Q15562 BCL2L15 Homo sapiens Q5TBC7
Y2H Array
25416956
Intra
TEAD2 Q15562 YAP1 Homo sapiens P46937
NMR
20368466
Intra
TEAD2 Q15562 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra
TEAD2 Q15562 YAP1 Homo sapiens P46937
Pull Down
20368466
Intra
TEAD2 Q15562 YAP1 Homo sapiens P46937
ITC
20368466
Intra
TEAD2 Q15562 YAP1 Homo sapiens P46937
BioID
35140242
Intra
TEAD2 Q15562 USF2 Homo sapiens Q15853
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

TEAD2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82377 Transcriptional Enhancer Factor TEF Antibody (YA2122) WB Human

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Spastic Paraplegia 24, Autosomal Recessive

SPG24

Spastic Paraplegia 24

Hereditary Spastic Paraplegia 24

Autosomal Recessive Spastic Paraplegia Type 24

Autosomal Recessive Spastic Paraplegia 24
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1221 Flufenamic acid 99.93% Unkown
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-B1221S1 Flufenamic acid-13C6 / Unkown
HY-158342 PROTAC TEAD degrader-1 Degrader / Unkown
HY-161568 TEAD-IN-10 Inhibitor / Unkown
HY-161569 TEAD-IN-11 Inhibitor / Unkown
HY-172113 H122 / Unkown
HY-B1221S Flufenamic acid-d4 / Unkown
HY-RS14343 TEAD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TEAD2 VGNC VGNC:47229
Mus musculus TEAD2 MGD MGI:104904
Bos taurus TEAD2 VGNC VGNC:35725
Felis catus TEAD2 VGNC VGNC:66054
Rattus norvegicus TEAD2 RGD RGD:1593252
Macaca mulatta TEAD2 VGNC VGNC:78302
Others TEAD2 NCBI